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Alexa Fluor 350標(biāo)記大鼠IgG（同型對(duì)照)保存條件 ：Store at 2-8℃ for one year. Avoid repeated freeze/thaw cycles.
二磷酸腺苷核糖基化因子6相互作用蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human ARL6: 31-120/186
細(xì)胞粘附分子相關(guān)蛋白/癌基因下調(diào)蛋白抗體注意事項(xiàng)；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: CDON (Cdo), which is implicated in myogenesis also has a role in human forebrain development. Holoprosencephaly (HPE), a common defect of human forebrain development, is associated with haploinsufficiency for genes encoding Sonic Hedgehog (SHH) pathway components. Cdo positiviely regulates SHH in multiple ways, including at signal reception and via a parallel mechanism required at the level of Gli transcription factors. Specific Cdo domains required for its promyogenic effect are dispensable for its Shh signaling role, suggesting that Cdo has multiple, independent functions.
腦多巴胺神經(jīng)營養(yǎng)因子抗體免 疫 原；KLH conjugated synthetic peptide derived from human ARMETL1: 101-187/187
Alexa Fluor 488標(biāo)記羊IgG（同型對(duì)照)保存條件 ：Store at 2-8℃ for one year. Avoid repeated freeze/thaw cycles.
維甲酸調(diào)節(jié)核基質(zhì)相關(guān)蛋白抗體注意事項(xiàng)；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Tissue specificity: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell. Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
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