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簡(jiǎn)要描述：黑色素聚集激素/黑色素富集激素MCH抗體免 疫 原；KLH conjugated synthetic peptide derived from human PMCH: 147-165/165
產(chǎn)品型號(hào)：GOY-01K2606廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：145產(chǎn)品分類
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黑色素聚集激素/黑色素富集激素MCH抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
黑色素聚集激素/黑色素富集激素MCH抗體 | PMCH | GOY-01K2606 |
商品屬性：
英文名稱: PMCH
中文名:黑色素聚集激素/黑色素富集激素MCH抗體
別 名；Melanin
concentrating hormone;PMCH; MCH_HUMAN; Pro MCH; Pro melanin concentrating
hormone.
研究領(lǐng)域；細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；16kDa
細(xì)胞定位；分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human PMCH: 147-165/165
亞 型；IgG
純化方法；affinity purified
by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
This gene encodes a soluble luminal protein with
two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a
complex with LAMN1 (lectin mannose binding protein 1; also known as ERGIC-53)
that facilitates the transport of coagulation factors V (FV) and VIII (FVIII)
from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic
reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene
cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive
bleeding disorder characterized by mild to moderate bleeding and coordinate
reduction in plasma FV and FVIII levels. This protein has also been shown to
maintain stem cell potential in adult central nervous system and is a marker
for testicular germ cell tumors. The 3' UTR of this gene contains a
transposon-like human repeat element named 'THE 1'. A processed RNA
pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results
in multiple transcript variants encoding distinct isoforms. [provided by
RefSeq, Jun 2010] MCH inhibits ACTH secretion at the end of the
light on period which corresponds to the peak of the circadian rhythm in
ACTH. Inhibits also stress induced ACTH release during the light off period
of the cycle. Involved as a neurotransmitter or neuromodulator in a broad array
of neuronal functions. Stimulates sexual behavior when injected into the
ventromedial nucleus, this effect is antagonized by NEI. In the medial
preoptic area, stimulates anxiety and sexual behavior. Antagonizes inhibitory
effect of melanotropin alpha on exploration behavior. NEI can influence differentiation of neuronal
processes in brain neurons. Affects the content of neurofilament protein in
neuritogenesis (in vitro). May also be a neuromodulatory factor. In
behavioral tests, it stimulates exploration and anxiety when injected into
the ventromedial nucleus. Also stimulates grooming, locomotion and rearing.
May antagonize the inhibitory effect of mch on ACTH release. Reduces dopamine
and dopac release in the ventromedial nucleus. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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