簡(jiǎn)要描述:Fyn結(jié)合蛋白抗體免 疫 原;KLH conjugated synthetic peptide derived from human FYB/ADAP: 501-600/783
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Fyn結(jié)合蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
Fyn結(jié)合蛋白抗體 | ADAP/FYB | GOY-01K1718 |
商品屬性:
英文名稱: ADAP/FYB
中文名:Fyn結(jié)合蛋白抗體
別 名;ADAP; Adhesion
and degranulation promoting adaptor protein; FYB 120/130; Fyb; FYB-120/130;
FYB_HUMAN; FYN binding protein; FYN T binding protein; FYN-binding protein;
FYN-T-binding protein; p120/p130; PRO0823; SLAP 130; SLAP-130; SLAP130; SLP 76
associated phosphoprotein; SLP-76-associated phosphoprotein; SLP76 associated
phosphoprotein.
研究領(lǐng)域;細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 結(jié)合蛋白 細(xì)胞類型標(biāo)志物
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;85kDa
細(xì)胞定位;細(xì)胞核 細(xì)胞漿
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human FYB/ADAP: 501-600/783
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件;Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Fyb (Fyn binding protein) and the anchoring
proteins SKAP55 (src kinase-associated phosphoprotein) and SKAP55-R
(SKAP55-related protein) associate with the tyrosine kinase p59fyn (1–3). SKAP55 and SKAP55-R bind to Fyb through their SH3
domains and function as substrates for p59Fyn in resting T cells (1–3). SKAP55 contains an amino-terminal pleckstrin homology domain
and a carboxy-terminal SH3 domain binding motif of adjacent arginine and
lysine residues followed by tandem tyrosines (i.e. RKxxYxxY) (4,5). SKAP55-R,
similar in overall structure to SKAP55, contains a coiled-coil N-terminal
domain (1,2). SKAP55 associates with SLAP-130, another component of the Fyn
complex, which plays a role in the regulation of signaling events initiated
by lymphocyte antigen receptors leading up to T cell activation (6). The
human Fyb gene maps to chromosome 5p13.1 and encodes a 783 amino acid protein
(7). Function: Acts as an adapter protein of the FYN and LCP2
signaling cascades in T cells. Modulates the expression of interleukin-2
(IL-2). Involved in platelet activation. Prevents the degradation of SKAP1
and SKAP2. |
多克隆抗體制備:
我公司合成抗原,保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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