簡要描述:α2巨球蛋白(α-2M)抗體免 疫 原;KLH conjugated synthetic peptide derived from human alpha 2 Macroglobulin: 751-850/1474
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α2巨球蛋白(α-2M)抗體
產品名稱 | 英文名稱 | 貨號 |
α2巨球蛋白(α-2M)抗體 | alpha 2 Macroglobulin | GOY-01K0081 |
商品屬性:
英文名稱: alpha 2 Macroglobulin
中文名:α2巨球蛋白(α-2M)抗體
別 名;A2M; α-2M; A2MG_HUMAN; Alpha 2 M; Alpha 2M; Alpha-2-M;
Alpha-2-macroglobulin; Alpha-2 Macroglobulin; Alpha 2-Macroglobulin; C3 and
PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5;
DKFZp779B086; FWP007; S863 7.
研究領域;細胞生物 免疫學 神經生物學
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應;Human,
Chicken, (predicted: Mouse, Rat, Pig,
Cow, Horse, Rabbit, )
產品應用;WB=1:500-2000
ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;160kDa
細胞定位;分泌型蛋白
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human alpha 2 Macroglobulin:
751-850/1474
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
Alpha-2-macroglobulin is a protease inhibitor and
cytokine transporter. It inhibits many proteases, including trypsin, thrombin
and collagenase. A2M is implicated in Alzheimer disease (AD) due to its
ability to mediate the clearance and degradation of A-beta, the major
component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]. Is able to inhibit all four classes of proteinases
by a unique 'trapping' mechanism. This protein has a peptide stretch, called
the 'bait region' which contains specific cleavage sites for different
proteinases. When a proteinase cleaves the bait region, a conformational
change is induced in the protein which traps the proteinase. The entrapped
enzyme remains active against low molecular weight substrates (activity
against high molecular weight substrates is greatly reduced). Following
cleavage in the bait region a thioester bond is hydrolyzed and mediates the
covalent binding of the protein to the proteinase. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達到1:32000,由蛋白抗原制備的多抗,保證WB檢測結果是陽性。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時,也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺,能為客戶提供各種類型的重組抗體表達服務,包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達,抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務,如動物免疫、動物飼養(yǎng)、抗體修飾服務(如FITC,HRP等的標記)、以及ELISA,WB,IHC,DB等檢測服務。
抗體定制服務:
已注冊商標,主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務,主要面向工業(yè)客戶。
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