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含錨蛋白重復序列-細胞因子信號抑制物盒蛋白家族2抗體
產品名稱 | 英文名稱 | 貨號 |
含錨蛋白重復序列-細胞因子信號抑制物盒蛋白家族2抗體 | ASB2 | GOY-01K1465 |
商品屬性:
英文名稱: ASB2
中文名:含錨蛋白重復序列-細胞因子信號抑制物盒蛋白家族2抗體
別 名;Ankyrin repeat
and SOCS box 2 containing protein; Ankyrin repeat and SOCS box containing 2;
Ankyrin repeat and SOCS box containing protein 2; Ankyrin repeat containing
protein ASB2.ASB2_HUMAN
研究領域;細胞生物 染色質和核信號 信號轉導 細胞周期蛋白 轉錄調節(jié)因子 表觀遺傳學
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應;(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, )
產品應用;WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;65kDa
細胞定位;細胞漿
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human ASB2: 501-587/587
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
The ankyrin repeat and SOCS box containing (ASB)
protein family is comprised of members which each contain "SOCS
boxes" but differ from other families of protein in the motifs they
contain upstream of the SOCS box. SOCS boxes are carboxy terminal regions of
homology found in the suppressor of cytokine signaling family of proteins.
The box region is thought to be the point of interaction between SOCS proteins
and E3 ubiquitin ligases. The SOCS box serves to couple suppressor of
cytokine signalling (SOCS) proteins and their binding partners with the
elongin B and C complex, possibly targeting them for degradation. The gene is
induced by all trans retinoic acid. In myeloid leukemia cells, the expression
of this encoded protein has been shown to induce growth inhibition and
chromatin condensation. Multiple alternatively spliced transcript variants
have been described for this gene but their full length sequences are not
known. Probable substrate-recognition component of a
SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase
complex which mediates the ubiquitination and subsequent proteasomal
degradation of target proteins |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達到1:32000,由蛋白抗原制備的多抗,保證WB檢測結果是陽性。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時,也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺,能為客戶提供各種類型的重組抗體表達服務,包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達,抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務,如動物免疫、動物飼養(yǎng)、抗體修飾服務(如FITC,HRP等的標記)、以及ELISA,WB,IHC,DB等檢測服務。
抗體定制服務:
已注冊商標,主要用于抗體藥物發(fā)現和開發(fā),是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務,主要面向工業(yè)客戶。
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