簡要描述:ASTE1蛋白抗體免 疫 原;KLH conjugated synthetic peptide derived from human ASTE1: 31-130/679
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ASTE1蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
ASTE1蛋白抗體 | ASTE1 | GOY-01K4217 |
商品屬性:
英文名稱: ASTE1
中文名:ASTE1蛋白抗體
別 名;ASTE1;
ASTE1_HUMAN; Asteroid homolog 1 (Drosophila); HT001; MGC129980;
OTTHUMP00000216085; Protein asteroid homolog 1.
研究領(lǐng)域;細(xì)胞生物 免疫學(xué)
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Rabbit, )
產(chǎn)品應(yīng)用;WB=1:500-2000
ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;77kDa
細(xì)胞定位;細(xì)胞漿 細(xì)胞膜
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human ASTE1: 31-130/679
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件;Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
ASTE1 is a 679 amino acid protein that belongs to
the asteroid family. Encoded by a gene that maps to human chromosome 3q22.1,
ASTE1 is conserved in chimpanzee, cow, mouse, rat and zebrafish. ASTE1 is
strongly linked to tumor-infiltrating lymphocytes in colorectal cancers with
microsatellite instability, with lymphocyte density correlating to frameshift
mutation presence and frequency within ASTE1. Severe colorectal dysplasia
with microsatellite instability also exhibits frameshift mutations within
ASTE1, suggesting that ASTE1 mutations occur early during microsatellite
instability-induced colorectal carcinogenesis. ASTE1 frameshift mutations may
generate a premature stop codon in the last exon that does not result in
nonsense-mediated mRNA decay, thereby allowing mutated ASTE1 proteins to be
highly expressed and exceptionally immunogenic. Frameshift mutations in ASTE1
are also linked to the manifestation of neoantigens, potentially recognized
by T cells, possibly resulting in specific immune responses against specific
neoantigens. Function: Possible role in EGF receptor signaling (By
similarity). |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時,也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺,能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù),如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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