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簡要描述：β淀粉樣前體蛋白裂解酶2抗體免 疫 原；KLH conjugated synthetic peptide derived from human BACE2: 101-200/518
產(chǎn)品型號：GOY-01K2462廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：527產(chǎn)品分類
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β淀粉樣前體蛋白裂解酶2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
β淀粉樣前體蛋白裂解酶2抗體 | BACE2 | GOY-01K2462 |
商品屬性：
英文名稱: BACE2
中文名:β淀粉樣前體蛋白裂解酶2抗體
別 名；ALP 56; ALP-56;
ALP56; ALP56; Asp 1; ASP1; ASP1; ASP21; Aspartic Like Protease 56kDa; Aspartic
Like Protease 56kDa; Aspartic-like protease 56 kDa; Aspartyl protease 1;
Aspartyl protease 1; BACE 2; BACE 2; Bace2; BACE2_HUMAN; Beta Secretase 2; Beta
Secretase 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2;
Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta-secretase
2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving
enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; Down
region aspartic protease; Downs Syndrome Region Aspartic Protease; Downs
Syndrome Region Aspartic Protease; DRAP; Memapsin 1; Memapsin1; Memapsin-1;
Membrane associated aspartic protease 1; Membrane-associated aspartic protease
1; Theta-secretase.
研究領(lǐng)域；細(xì)胞生物 神經(jīng)生物學(xué) Alzheimer's
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；Mouse,
Rat, (predicted: Dog, )
產(chǎn)品應(yīng)用；IHC-P=1:100-500
IHC-F=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；50kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞膜 細(xì)胞外基質(zhì)
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human BACE2: 101-200/518
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Cerebral deposition of amyloid beta peptide is an
early and critical feature of Alzheimer's disease and a frequent complication
of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage
of amyloid precursor protein by 2 proteases, one of which is the protein
encoded by this gene. This gene localizes to the 'Down critical region' of
chromosome 21. The encoded protein, a member of the peptidase A1 protein
family, is a type I integral membrane glycoprotein and aspartic protease.
Three transcript variants encoding different isoforms have been described for
this gene. [provided by RefSeq, Jul 2008]. Responsible for the proteolytic processing of the
amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691,
leading to the generation and extracellular release of beta-cleaved soluble
APP, and a corresponding cell-associated C-terminal fragment which is later
released by gamma-secretase. It has also been shown that it can cleave APP
between residues 671 and 672. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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