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簡要描述：抗利尿激素受體1B抗體免 疫 原；KLH conjugated synthetic peptide derived from human AVP Receptor V3: 23-120/424
產(chǎn)品型號：GOY-01K2027廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：532產(chǎn)品分類
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抗利尿激素受體1B抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
抗利尿激素受體1B抗體 | AVPR1B | GOY-01K2027 |
商品屬性：
英文名稱: AVPR1B
中文名:抗利尿激素受體1B抗體
別 名；AVP Receptor V3;
Antidiuretic hormone receptor 1b; Arginine vasopressin receptor 1B; Arginine
vasopressin receptor 3; AVPR V1b; AVPR V3; Avpr1b; AVPR3; Pituitary vasopressin
receptor 3; V1bR; V1BR_HUMAN; Vasopressin V1b receptor; Vasopressin V3
receptor; VPR3.
研究領域；神經(jīng)生物學 信號轉導 生長因子和激素 細胞膜受體 G蛋白偶聯(lián)受體 G蛋白信號 細胞膜蛋白
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；47kDa
細胞定位；細胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human AVP Receptor V3: 23-120/424
<Extracellular>
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Vasopressin (AVP), the antidiuretic hormone, is a
cyclic nonpeptide that is involved in the regulation of body fluid osmolality
(1-3). AVP mediates its effects through a family of G-protein coupled
receptors, the vasopressin receptors type V1a, V2 and V3 (also designated
V1b) (1,2). The AVP receptor V1a is responsible for several functions,
including blood vessel constriction, liver glycogenolysis and platelet
adhesion (3). It is detected as a full length protein and a shorter protein,
which results from proteolytic cleavage of its amino terminus (4). The V1a
receptor is coupled to Gq/11 protein, which increases the intracellular
calcium concentration (3). The human AVP receptor V2 gene maps to chromosome
Xq28 and is expressed in lung and kidney (5,6). Mutations in the V2 receptor
result in nephrogenic diabetes insipidus (NDI), a rare X-linked disorder
characterized by the inability of the kidney to concentrate urine in response
to AVP (5,7). The AVP Receptor V2 activates the Gs protein and the cyclic AMP
second messenger system (7). The AVP receptor V3 is preferentially expressed
in the pituitary and stimulates the release of adrenocorticotropic hormone
(ACTH) in response to AVP by mobilizing intracellular calcium stores (8). AVP
receptor antagonists may have potential therapeutic effects in hypertension,
congestive heart failure, nephrotic syndrome and ACTH-secreting tumors (2). Receptor for arginine vasopressin. The activity of
this receptor is mediated by G proteins which activate a
phosphatidyl-inositol-calcium second messenger system. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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