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簡要描述：α2巨球蛋白樣蛋白1抗體 α2ML1免 疫 原；KLH conjugated synthetic peptide derived from human A2ML1: 31-130/1454
產(chǎn)品型號：GOY-01K1267廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：592產(chǎn)品分類
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α2巨球蛋白樣蛋白1抗體 α2ML1
產(chǎn)品名稱 | 英文名稱 | 貨號 |
α2巨球蛋白樣蛋白1抗體 α2ML1 | A2ML1 | GOY-01K1267 |
商品屬性：
英文名稱: A2ML1
中文名:α2巨球蛋白樣蛋白1抗體 α2ML1
別 名；A2ML 1; Alpha 2
macroglobulin like 1; Alpha 2 macroglobulin like protein 1; C3 and PZP like
alpha 2 macroglobulin domain containing protein 9; CPAMD9; DKFZp686C1729;
DKFZp686D2011; DKFZp686G1812; DKFZp686L1821; DKFZp686O1010; FLJ16045; FLJ25179;
FLJ39129; FLJ41597; FLJ41598; FLJ41607; A2ML1_HUMAN. α2ML1
研究領(lǐng)域；細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Horse, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；159kDa
細(xì)胞定位；細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human A2ML1: 31-130/1454
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
alpha-2-Macroglobulin (alpha-2M) is a
homotetrameric serum protein consisting of four identical subunits that form
dimers through disulfide bonds. Initially, alpha-2M was characterized as a
pan-proteinase inhibitor that was able to “bait” proteinases into cleaving specific
peptide sequences on alpha-2M. This interaction induces a conformational
change in alpha-2M, thus enabling it to “trap” the proteinase and further inhibit its activity. Subsequently,
alpha-2M has been shown to function as a carrier protein and regulator of
cytokines during inflammation. Circulating transforming growth factor beta
(TGF beta) in serum is primarily bound to alpha-2M, which renders TGF∫ inactive. Mutations and deletions in the gene encoding alpha-2M
are associated with an increased incidence of Alzheimer's Disease (AD).
Alpha-2-macroglobulin-like protein 1 (alpha2ML1) is a related protein that is
expressed in the epidermis and may play a role in keratinocyte
differentiation. A2ML1 is a new member of the alpha 2-macroglobulin
protease inhibitor family, and shares most the characteristics of this
family. It is the first family member detected in the epidermis and may play
an important role during desquamation by inhibiting extracellular proteases.
The alpha-macroglobulin (AM) superfamily of proteins contains both complement
components and protease inhibitors, including A2M and A2ML1. AM proteins
display a unique trap mechanism of inhibition, by which the AM inhibitor
undergoes a major conformational change upon its cleavage by a protease, thus
trapping the protease and blocking it from subsequent substrate binding. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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