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簡要描述：泛素蛋白連接酶E3α2抗體免 疫 原；KLH conjugated synthetic peptide derived from human UBR2: 801-900/1755
產品型號：GOY-01K1905廠商性質：科研更新時間：2023-10-24 00:00:00訪 問 量：171產品分類
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泛素蛋白連接酶E3α2抗體
產品名稱 | 英文名稱 | 貨號 |
泛素蛋白連接酶E3α2抗體 | UBR2 | GOY-01K1905 |
商品屬性：
英文名稱: UBR2
中文名:泛素蛋白連接酶E3α2抗體
別 名；E3 ubiquitin
protein ligase UBR2; N recognin 2; Ubiquitin ligase E3 alpha II; Ubiquitin
protein ligase E3 alpha 2; Ubiquitin protein ligase E3 component n recognin 2;
UBR 2; UBR2_HUMAN; N-recognin-2; Ubiquitin-protein ligase E3-alpha-2;
Ubiquitin-protein ligase E3-alpha-II.
研究領域；細胞生物 免疫學 發(fā)育生物學
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；44kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human UBR2: 801-900/1755
亞 型；IgG
純化方法；affinity purified
by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
Ubiquitination is an important mechanism through
which three classes of enzymes act in concert to target short-lived or
abnormal proteins for destruction. The three classes of enzymes involved in
ubiquitination are the ubiquitin-activating enzymes (E1s), the
ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s).
Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a
1755 amino acid protein that contains one UBR-type zinc finger and one
RING-type zinc finger. Participating in protein modification events within
the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that
recognizes and binds proteins that contain destabilizing N-terminal residues,
thereby leading to their ubiquitination and subsequent degradation. Mice
lacking Ubr2 are infertile due to defects in male meiosis. E3 ubiquitin-protein ligase which is a component
of the N-end rule pathway. Recognizes and binds to proteins bearing specific
N-terminal residues that are destabilizing according to the N-end rule,
leading to their ubiquitination and subsequent degradation. Plays a critical
role in chromatin inactivation and chromosome-wide transcriptional silencing
during meiosis via ubiquitination of histone H2A. Binds leucine and is a
negative regulator of the leucine-mTOR signaling pathway, thereby controlling
cell growth. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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