簡(jiǎn)要描述:TGFB1誘導(dǎo)抗凋亡因子1抗體免 疫 原;KLH conjugated synthetic peptide derived from human TIAF1: 34-115/115
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TGFB1誘導(dǎo)抗凋亡因子1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
TGFB1誘導(dǎo)抗凋亡因子1抗體 | TIAF1 | GOY-01K0848 |
商品屬性:
英文名稱: TIAF1
中文名:TGFB1誘導(dǎo)抗凋亡因子1抗體
別 名;MAJN; TGFB1
induced anti apoptotic factor 1 (12 kDa TGF beta1 induced antiapoptotic
factor); 12 kDa TGF-beta-1-induced antiapoptotic factor; TGFB1 induced anti
apoptotic factor 1; TGFB1-induced anti-apoptotic factor 1; TIAF1_HUMAN; MAJN;
SPR210; MYO18A; MYSPDZ; TGFB1 induced anti apoptotic factor 1.
研究領(lǐng)域;細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子
抗體來(lái)源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);Human,
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in other
applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;12kDa
細(xì)胞定位;細(xì)胞核
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human TIAF1: 34-115/115
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
TIAF-1 (TGF Beta 1-induced antiapoptotic factor
1), also known as MYO18A, MAJN or MYSPDZ, is a TGF Beta 1-induced
anti-apoptotic factor that localizes to the nucleus and functions to inhibit
the cytotoxic effects of TNF? TRADD and FADD. Two isoforms of mouse TIAF-1
exist and are designated MysPDZ-Alpha and MysPDZ-Beta. MysPDZ-Alpha consists
of a KE-rich region, an N-terminal PDZ domain and a prevalent myosin
homologous head region, while the MysPDZ-Beta isoform lacks the KE-rich
region and PDZ domain. MysPDZ-Alpha is present in most tissues and is known
to co-localize with the ER-Golgi complex and with membrane ruffles and
filopodia. MysPDZ-Beta is expressed specifically in hematopoietic tissues and
cell lines and shows dispersed localization in the cytoplasm. This protein inhibits the cytotoxic effects of
TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIP. It is
involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression
of TNF-mediated IkappaB-alpha degradation. |
多克隆抗體制備:
我公司合成抗原,保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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