簡(jiǎn)要描述:TANK抗體免 疫 原;KLH conjugated synthetic peptide derived from human TANK: 151-260/425
產(chǎn)品分類
Product Category相關(guān)文章
Related Articles詳細(xì)介紹
TANK抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
TANK抗體 | TANK | GOY-01K2046 |
商品屬性:
英文名稱: TANK
中文名:TANK抗體
別 名;I TRAF; ITRAF;
TRAF family member associated NF KAPPA B activator; TRAF family member
associated NFKB activator; TRAF interacting protein; TRAF interacting protein
TANK isoform a; I-TRAF; Tank; TANK_HUMAN; TRAF family member-associated
NF-kappa-B activator; TRAF-interacting protein; TRAF interacting protein TANK
isoform b; TRAF2.
研究領(lǐng)域;細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量;48kDa
細(xì)胞定位;細(xì)胞核 細(xì)胞漿
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human TANK: 151-260/425
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M TBS(pH7.4)
with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
TANK was initially identified as a novel
TRAF-interacting protein that regulated TRAF-mediated signal transduction.
Specifically, ligand binding by surface receptors in the tumor necrosis
factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to
the formation of a TRAF/TANK complex that mediates the activation of the
transcription factor NF-kappaB. TANK is found in the cytoplasm and can bind
to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering
the TRAFs in a latent state in the cytoplasm. For example, this protein can
block TRAF2 binding to LMP1, the Epstein Barr virus transforming protein, and
inhibit LMP1-mediated NF kappa B activation. Acts as a regulator of TRAF function by
maintaining them in a latent state. Overexpression inhibits TRAF2-mediated
NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding
to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in
I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases
such as TBK1 or IKBKE that can modulate IKK activity. |
多克隆抗體制備:
我公司合成抗原,保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
產(chǎn)品咨詢
歡迎您關(guān)注我們的微信了解更多信息
電話
微信掃一掃