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SPOP蛋白抗體
產品名稱 | 英文名稱 | 貨號 |
SPOP蛋白抗體 | SPOP | GOY-01K1505 |
商品屬性:
英文名稱: SPOP
中文名:SPOP蛋白抗體
別 名;BTBD32; TEF2;
SPOP_HUMAN; Speckle-type POZ protein; HIB homolog 1; Roadkill homolog 1.
研究領域;發(fā)育生物學
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應;(predicted:
Human, Mouse, Rat, )
產品應用;WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;41kDa
細胞定位;細胞核
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human SPOP: 101-200/374
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項;This product
as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
This gene encodes a protein that may modulate the
transcriptional repression activities of death-associated protein 6 (DAXX),
which interacts with histone deacetylase, core histones, and other
histone-associated proteins. In mouse, the encoded protein binds to the
putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is
enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has
been shown in other proteins to mediate transcriptional repression and to
interact with components of histone deacetylase co-repressor complexes.
Alternative splicing of this gene results in multiple transcript variants encoding
the same protein. [provided by RefSeq, Jul 2008]. Component of a cullin-RING-based BCR
(BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the
ubiquitination of target proteins, leading most often to their proteasomal
degradation. In complex with CUL3, involved in ubiquitination and proteasomal
degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3,
involved in ubiquitination of H2AFY and BMI1; this does not lead to their
proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1
targets, such as insulin, by promoting PDX1/IPF1 degradation. The
cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex
containing homodimeric SPOP has higher ubiquitin ligase activity than the
complex that contains the heterodimer formed by SPOP and SPOPL. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達到1:32000,由蛋白抗原制備的多抗,保證WB檢測結果是陽性。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時,也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺,能為客戶提供各種類型的重組抗體表達服務,包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達,抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務,如動物免疫、動物飼養(yǎng)、抗體修飾服務(如FITC,HRP等的標記)、以及ELISA,WB,IHC,DB等檢測服務。
抗體定制服務:
已注冊商標,主要用于抗體藥物發(fā)現和開發(fā),是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務,主要面向工業(yè)客戶。
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