歡迎來到上海谷研實業(yè)有限公司網(wǎng)站！
咨詢電話：18321818584歡迎來到上海谷研實業(yè)有限公司網(wǎng)站！咨詢電話：18321818584
簡要描述：ATP依賴解旋酶SMARCA2抗體免 疫 原；KLH conjugated synthetic peptide derived from human SMARCA2/BRM: 1401-1590/1590
產品型號：GOY-01K2668廠商性質：科研更新時間：2023-10-24 00:00:00訪 問 量：162產品分類
Product Category相關文章
Related Articles詳細介紹
ATP依賴解旋酶SMARCA2抗體
產品名稱 | 英文名稱 | 貨號 |
ATP依賴解旋酶SMARCA2抗體 | SMARCA2 | GOY-01K2668 |
商品屬性：
英文名稱: SMARCA2
中文名:ATP依賴解旋酶SMARCA2抗體
別 名；BRM; ATP
dependent helicase SMARCA2; Global transcription activator homologous sequence;
BRG1-associated factor 190B; BAF190B; hBRM; hSNF2a; Possible global
transcription activator SNF2L2 (EC:3.6.4.-); SMARCA2; SMCA2_HUMAN; SNF2 alpha;
SNF2 like 2; SNF2/SWI2 like protein 2; SNF2A; SNF2LA; SNF2L2; Sth1p; SWI/SNF
related matrix associated actin dependent regulator of chromatin subfamily a
member 2.
研究領域；細胞生物 免疫學 表觀遺傳學
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；Rat, (predicted: Human, Mouse, Dog, Pig, Cow,
Horse, Rabbit, )
產品應用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；230kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human SMARCA2/BRM: 1401-1590/1590
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human, therapeutic
or diagnostic applications.
產品介紹:
A transcriptional coactivator cooperating with
nuclear hormone receptors to potentiate transcriptional activation. SMARCA2 /
BRM belongs to the SNF2/RAD54 helicase family, is a homologue of the
Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma proteins. It
contains a methyl lysine containing bromo domain and an HSA domain. The yeast
protein SNF2, also known as SWI2, is involved in transcriptional activation
of numerous genes. It contains a domain that is highly conserved among
several known helicases and is required for transcriptional activity.
SNF2/SWI2 is highly homologous to the Drosophila protein 'brahma' (brm).
Although the 2 proteins show nuclear localization during interphase, they are
excluded from the condensed chromosomes during mitosis. They found that the
level of BRM, but not BRG1, was strongly reduced during mitosis.
Phosphorylation of hbrm and BRG1 did not disrupt their association with SNF5
but correlated with a decreased affinity for the nuclear structure in early M
phase. Function: Transcriptional coactivator cooperating with
nuclear hormone receptors to potentiate transcriptional activation. Also
involved in vitamin D-coupled transcription regulation via its association
with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D
receptor (VDR), which is required for the ligand-bound VDR-mediated
transrepression of the CYP27B1 gene. Belongs to the neural
progenitors-specific chromatin remodeling complex (npBAF complex) and the
neuron-specific chromatin remodeling complex (nBAF complex). During neural
development a switch from a stem/progenitor to a post-mitotic chromatin
remodeling mechanism occurs as neurons exit the cell cycle and become
committed to their adult state. The transition from proliferating neural
stem/progenitor cells to post-mitotic neurons requires a switch in subunit
composition of the npBAF and nBAF complexes. As neural progenitors exit
mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A
and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and
DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The
npBAF complex is essential for the self-renewal/proliferative capacity of the
multipotent neural stem cells. The nBAF complex along with CREST plays a role
regulating the activity of genes essential for dendrite growth (By
similarity). |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
產品咨詢
電話
微信掃一掃
聯(lián)系人：銷售部
地址：上海市嘉定區(qū)澄瀏公路52號盛創(chuàng)企業(yè)
郵箱：3004918891@qq.com
手機：18321818584 / 15026555973