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簡(jiǎn)要描述：雌激素調(diào)節(jié)蛋白LIV1/鋅轉(zhuǎn)運(yùn)蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human SLC39A6: 251-350/755
產(chǎn)品型號(hào)：GOY-01K0223廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：156產(chǎn)品分類
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雌激素調(diào)節(jié)蛋白LIV1/鋅轉(zhuǎn)運(yùn)蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
雌激素調(diào)節(jié)蛋白LIV1/鋅轉(zhuǎn)運(yùn)蛋白抗體 | SLC39A6 | GOY-01K0223 |
商品屬性：
英文名稱: SLC39A6
中文名:雌激素調(diào)節(jié)蛋白LIV1/鋅轉(zhuǎn)運(yùn)蛋白抗體
別 名；LIV1; LIV 1;
LIV-1; solute carrier family 39, member 6; solute carrier family 39 (zinc
transporter), member 6 isoform 1; Zinc transporter ZIP6; Zrt- and Irt-like
protein 6; ZIP-6; Endoplasmic reticulum membrane-linked protein; Ermelin;
S39A6_HUMAN.
研究領(lǐng)域；信號(hào)轉(zhuǎn)導(dǎo)
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；82kDa
細(xì)胞定位；細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human SLC39A6: 251-350/755
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
LIV-1 is expressed as two isoforms. LIV-1 is a
multi-pass cell membrane protein that is 749 amino acids in length and is
expressed abundantly in breast, prostate, placenta, kidney, pituitary and
corpus callosum, as well as in cells derived from various types of cancers
affecting the glands, cervix and lungs. LIV-1 is a member of the ZIP
transporter protein family which consists of 14 members that transport zinc.
LIV-1 transports zinc from its position on the plasma membrane into the
cytosol of the cell and contains a histidine-rich transmembrane domain which
is thought to bind zinc and aid in its transportation. LIV-1 is thought to be
important for zinc uptake in neuroblastoma cells and may also be crucial for
maintaining zinc homeostasis, a process which aids in the prevention of
cancer and disease. Activated estrogen receptors are thought to regulate
LIV-1 expression at the level of transcription, via the mRNA precursor to
LIV-1 which associates with estrogen receptors that are activated by growth
factors and estradiol. LIV-1 is upregulated in hormone-rich tissue, including
breast and cervical cancer, where it is thought to affect cell motility and may
play an important role in tumor development and metastasis. Conversely, less
aggressive tumors may contain high levels of LIV-1 that could lead to
apoptosis, indicating a dual role for LIV-1 in tumor suppression. May act as a zinc-influx transporter. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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