簡要描述:鉀氯離子轉(zhuǎn)運蛋白3抗體免 疫 原;KLH conjugated synthetic peptide derived from human SLC12A6/KCC3: 401-500/1150
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鉀氯離子轉(zhuǎn)運蛋白3抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
鉀氯離子轉(zhuǎn)運蛋白3抗體 | SLC12A6 | GOY-01K1691 |
商品屬性:
英文名稱: SLC12A6
中文名:鉀氯離子轉(zhuǎn)運蛋白3抗體
別 名;ACCPN; Furosemide
sensitive KCl cotransporter 3; Gaxp; KCC 3; KCC 3A; KCC 3B; KCC3 A; KCC3; KCC3
B; KCC3A; KCC3B; Potassium chloride cotransporter 3; Potassium chloride
cotransporter KCC3a S3; SLC12 A6; SLC12A 6; Solute carrier family 12
(potassium/chloride transporters), member 6; Solute carrier family 12, member
6; S12A6_HUMAN.
研究領域;心血管 神經(jīng)生物學 通道蛋白 轉(zhuǎn)運蛋白
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應;(predicted:
Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量;128kDa
細胞定位;細胞膜
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human SLC12A6/KCC3: 401-500/1150
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The four isoforms of potassium/chloride
co-transport channels (KCC) belong to a superfamily of cation-chloride
co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors
activate KCCs, while inhibitors of the cGMP pathway prevent NO donor
activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains
with both cytoplasmic N and C terminal domains. KCC2 expression is limited to
neuronal tissues by a restrictive element similar to the neuronal-restrictive
silencing factor. In neurons, KCC2 expression is correlated with an
inhibitory response to GABA, while the absence of KCC2 is necessary for an
unusual excitatory response to GABA. Alterations of KCC2 expression in the
inferior colliculus of rat brain may be related to seizure susceptibility.
Conversely, KCC3 is not suspected to play a major role in epilepsy. The two
splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in
brain and kidney, respectively, while KCC4 is expressed in muscle, brain,
lung, heart and kidney. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達到1:32000,由蛋白抗原制備的多抗,保證WB檢測結果是陽性。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時,也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺,能為客戶提供各種類型的重組抗體表達服務,包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達,抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務,如動物免疫、動物飼養(yǎng)、抗體修飾服務(如FITC,HRP等的標記)、以及ELISA,WB,IHC,DB等檢測服務。
抗體定制服務:
已注冊商標,主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務,主要面向工業(yè)客戶。
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