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簡要描述：紡錘體和著絲粒相關(guān)蛋白2抗體注意事項；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品型號：GOY-01K2180廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：159產(chǎn)品分類
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紡錘體和著絲粒相關(guān)蛋白2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
紡錘體和著絲粒相關(guān)蛋白2抗體 | SKA2 | GOY-01K2180 |
商品屬性：
英文名稱: SKA2
中文名:紡錘體和著絲粒相關(guān)蛋白2抗體
別 名；FAM33A; Family
with sequence similarity 33, member A; FLJ12758; MGC110975; Protein FAM33A; SKA
2; SKA2; SKA2_HUMAN; Spindle and kinetochore associated complex subunit 2;
Spindle and kinetochore associated protein 2; Spindle and
kinetochore-associated protein 2; Spindle and KT (kinetochore) associated 2;
Spindle and KT associated 2.
研究領(lǐng)域；細胞生物 細胞周期蛋白 細胞分化
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；14kDa
細胞定位；細胞核 細胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human SKA2: 2-88/121
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M TBS(pH7.4)
with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Ska2 (spindle and kinetochore associated complex
subunit 2), also known as FAM33A, is a 121 amino acid component of the Ska1
complex, a microtubule-binding subcomplex of the outer kinetochore that is
critical for proper chromosome segregation. The Ska1 complex is a component
of the kinetochore-microtubule interface and directly associates with
microtubules as oligomeric assemblies. Localized to the outer kinetochore and
spindle microtubules during cell proliferation, Ska2 is essential for spindle
checkpoint silencing and exit from mitosis. Downregulation of Ska2 leads to
delayed recruitment of MAD2, a component of the mitotic spindle checkpoint,
to several kinetochores resulting in occasional loss of individual
chromosomes from the metaphase plate. Ska2 is encoded by a gene located on
human chromosome 17, which comprises over 2.5% of the human genome and
encodes over 1,200 genes. Component of the SKA1 complex, a
microtubule-bindingsubcomplex of the outer kinetochore that is essential for
properchromosome segregation. Required for timely anaphase onset
duringmitosis, when chromosomes undergo bipolar attachment on
spindlemicrotubules leading to silencing of the spindle checkpoint. TheSKA1
complex is a direct component of the kinetochore-microtubuleinterface and
directly associates with microtubules as oligomericassemblies. The complex
facilitates the processive movement ofmicrospheres along a microtubule in a
depolymerization-coupledmanner. In the complex, it is required for SKA1
localization. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術(shù)服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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