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簡(jiǎn)要描述：辛諾柏病毒糖VP8抗體免 疫 原；KLH conjugated synthetic peptide derived from Simian Rotavirus VP8: 1-100/776aa
產(chǎn)品型號(hào)：GOY-01K2602廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：159產(chǎn)品分類
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辛諾柏病毒糖VP8抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
辛諾柏病毒糖VP8抗體 | Simian Rotavirus VP8 | GOY-01K2602 |
商品屬性：
英文名稱: Simian Rotavirus VP8
中文名:辛諾柏病毒糖VP8抗體
別 名；Simian Rotavirus
VP8/VP4; Simian Rotavirus VP8 + VP4; Outer capsid protein VP8; Hemagglutinin;
VP4_ROTSS; Outer Capsid protein VP4 (Hemagglutinin); Outer capsid protein VP4;
RVA s4gp1; RVAs4gp1; VP4; Outer capsid protein VP4; Outer capsid protein VP8*;
Simian Rotavirus VP8*. 外層衣殼蛋白VP8; 猴輪狀病毒VP8
研究領(lǐng)域；細(xì)胞生物 細(xì)菌及病毒
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；26/87kDa
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from Simian Rotavirus VP8: 1-100/776aa
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹:
Simian Rotavirus VP4 (Outer Capsid protein VP4)
(Hemagglutinin) functions as a spike-forming protein that mediates virion attachment
to the host epithelial cell receptors and plays a major role in cell
penetration, determination of host range restriction and virulence. Rotavirus
entry into the host cell probably involves multiple sequential contacts
between the outer capsid proteins VP4 and VP7, and the cell receptors.
According to the considered strain, VP4 seems to essentially target sialic
acid and/or the integrin heterodimer ITGA2/ITGB1. VP4 is a homotrimer and
adopts a dimeric appearance above the capsid surface, while forming a
trimeric base anchored inside the capsid layer. The priming trypsin cleavage
triggers its rearrangement into rigid spikes with approximate two-fold
symmetry of their protruding parts. After an unknown second triggering event,
cleaved VP4 may undergo another rearrangement, in which two VP5* subunits
fold back on themselves and join a third subunit to form a tightly associated
trimer, shaped like a folded umbrella. VP4 interacts with host ITGA2 (via
ITAG2 I-domain); this interaction occurs when ITGA2 is part of the integrin
heterodimer ITGA2/ITGB1. VP4 interacts with host integrin heterodimer
TGA4/ITGB1 and ITGA4/ITGB7. Proteolytic cleavage by trypsin results in
activation of VP4 functions and greatly increases infectivity. The
penetration into the host cell is dependent on trypsin treatment of VP4. It
produces two peptides, VP5* and VP8* that remain associated with the virion. Function: Outer capsid protein VP5*: forms the spike 'foot'
and 'body'. Acts as a membrane permeabilization protein that mediates release
of viral particles from endosomal compartments into the cytoplasm. In
integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1
for cell attachment (By similarity). VP8* forms the head of the spikes. It is the viral
hemagglutinin and an important target of neutralizing antibodies. In sialic
acid-dependent strains, VP8* binds to host cell sialic acid, most probably a
ganglioside, providing the initial contact. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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