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簡(jiǎn)要描述：環(huán)指蛋白146抗體免 疫 原；KLH conjugated synthetic peptide derived from human RNF146: 95-160/359
產(chǎn)品型號(hào)：GOY-01K2296廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：180產(chǎn)品分類(lèi)
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環(huán)指蛋白146抗體
產(chǎn)品名稱(chēng) | 英文名稱(chēng) | 貨號(hào) |
環(huán)指蛋白146抗體 | RNF146 | GOY-01K2296 |
商品屬性：
英文名稱(chēng): RNF146
中文名:環(huán)指蛋白146抗體
別 名；Dactylidin;
dJ351K20.1; DKFZP434O1427; E3 ubiquitin-protein ligase rnf146; RING finger
protein 146; RN146_HUMAN; RNF 146; Rnf146; RP3 351K20.1.
研究領(lǐng)域；環(huán)指蛋白
抗體來(lái)源；Rabbit
克隆類(lèi)型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；39kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human RNF146: 95-160/359
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The RING-type zinc finger motif is present in a
number of viral and eukaryotic proteins and is made of a conserved
cysteine-rich domain that is able to bind two zinc atoms. Proteins that
contain this conserved domain are generally involved in the ubiquitination
pathway of protein degradation. RNF146 (RING finger protein 146), also known
as Dactylidin, is a 359 amino acid protein that contains one RING-type zinc
finger and one WWE domain. Via its RING-type zinc finger, RNF146 may play a role
in transcriptional regulation and protein degradation events. Defects in the
gene encoding RNF146 are associated with Alzheimer's disease (AD) and may
lead to a higher risk of breast cancer. Two isoforms of RNF146 exist due to
alternative splicing events. E3 ubiquitin-protein ligase that specifically
binds poly-ADP-ribosylated proteins and mediates their ubiquitination and
subsequent degradation. Acts as an activator of the Wnt signaling pathway by
mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key
components of the beta-catenin destruction complex. Acts in cooperation with
tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of
target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and
binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain
and mediates their ubiquitination. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
鼠單克隆抗體制備:
客戶(hù)可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專(zhuān)業(yè)的建議。在制備過(guò)程中，與客戶(hù)互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿(mǎn)足客戶(hù)抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶(hù)提供各種類(lèi)型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶(hù)提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶(hù)量身定制的專(zhuān)業(yè)服務(wù)，主要面向工業(yè)客戶(hù)。
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