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簡(jiǎn)要描述：蛋白C抑制因子抗體免 疫 原；KLH conjugated synthetic peptide derived from human Protein C inhibitor: 251-350/406
產(chǎn)品型號(hào)：GOY-01K2785廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：151產(chǎn)品分類
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蛋白C抑制因子抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
蛋白C抑制因子抗體 | Protein C inhibitor | GOY-01K2785 |
商品屬性：
英文名稱: Protein C inhibitor
中文名:蛋白C抑制因子抗體
別 名；Acrosomal serine
protease inhibitor; IPSP; PAI 3; PAI3; PCI; PLANH 3; PLANH3; Plasma serine
protease inhibitor; Plasminogen activator inhibitor 3; Plasminogen activator
inhibitor III; PROCI; Serpin A5; Serpin peptidase inhibitor clade A (alpha 1
antiproteinase antitrypsin) member 5; Serpin peptidase inhibitor clade A member
5; SerpinA5; IPSP_HUMAN.
研究領(lǐng)域；腫瘤 心血管 免疫學(xué) 細(xì)胞凋亡
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；43kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞膜 細(xì)胞外基質(zhì) 分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Protein C inhibitor: 251-350/406
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Protein C Inhibitor (PCI), a member of the serine
protease inhibitor (serpin) superfamily, is abundant in plasma and other body
fluids. Protein C Inhibitor inhibits a number of "arginine
specific" serine proteases of the coagulation and fibrinolytic systems
(including thrombin, trypsin, and activated Protein C), as well as plasma and
tissue kallikreins and the sperm protease acrosin. This inhibition is
regulated by glycosaminoglycans, such as heparin and heparan sulphate, and
several polyanions. As well as its roles in the regulation of hemostasis and
fertilisation, Protein C Inhibitor is involved in cell inflammation,
proliferation, apoptosis, tumour cell migration, invasion, and metastasis.
Recent studies have demonstrated an association between Protein C Inhibitor
and multiple sclerosis lesions. Heparin-dependent serine protease inhibitor acting
in body fluids and secretions. Inactivates serine proteases by binding
irreversibly to their serine activation site. Involved in the regulation of
intravascular and extravascular proteolytic activities. Plays hemostatic
roles in the blood plasma. Acts as a procoagulant and proinflammatory factor
by inhibiting the anticoagulant activated protein C factor as well as the
generation of activated protein C factor by the thrombin/thrombomodulin
complex. Acts as an anticoagulant factor by inhibiting blood coagulation
factors like prothrombin, factor XI, factor Xa, plasma kallikrein and
fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators.
In seminal plasma, inactivates several serine proteases implicated in the
reproductive system. Inhibits the serpin acrosin; indirectly protects
component of the male genital tract from being degraded by excessive released
acrosin. Inhibits tissue-and urinary-type plasminogen activator,
prostate-specific antigen and kallikrein activities; has a control on the
sperm motility and fertilization. Inhibits the activated protein C-catalyzed
degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during
the process of transfer of spermatozoa from the male reproductive tract into
the female tract. In urine, inhibits urinary-type plasminogen activator and
kallikrein activities. Inactivates membrane-anchored serine proteases
activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen
activator-dependent tumor cell invasion and metastasis. May also play a
non-inhibitory role in seminal plasma and urine as a hydrophobic hormone
carrier by its binding to retinoic acid. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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