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簡(jiǎn)要描述：蛋白激酶C zeta 抗體免 疫 原；KLH conjugated synthetic peptide derived from human PKC zeta: 61-160/592
產(chǎn)品型號(hào)：GOY-01K0681廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：155產(chǎn)品分類
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蛋白激酶C zeta 抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
蛋白激酶C zeta 抗體 | PKC zeta | GOY-01K0681 |
商品屬性：
英文名稱: PKC zeta
中文名:蛋白激酶C zeta 抗體
別 名；AI098070;
aPKCzeta; C80388; EC 2.7.11.13; KPCZ_HUMAN; nPKC zeta; nPKC-zeta;
OTTHUMP00000001368; OTTHUMP00000044160; PKC 2; PKC ZETA; PKC2; Pkcz; PKCZETA;
PKM-zeta, included; PRKCZ; Protein kinase C zeta; Protein kinase C zeta form;
Protein kinase C zeta type; r14-3-3; R74924; zetaPKC; PKC-ZETA; PKC2;
nPKC-zeta.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；66kDa
細(xì)胞定位；細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human PKC zeta: 61-160/592
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Protein kinase C (PKC) zeta is a member of the PKC
family of serine/threonine kinases which are involved in a variety of
cellular processes such as proliferation, differentiation and secretion.
Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta
exhibits a kinase activity which is independent of calcium and diacylglycerol
but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC
inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC
isoenzymes, it has only a single zinc finger module. These structural and
biochemical properties indicate that the zeta subspecies is related to, but
distinct from other isoenzymes of PKC. Alternative splicing results in
multiple transcript variants encoding different isoforms. [provided by
RefSeq, Jul 2008]. Calcium- and diacylglycerol-independent
serine/threonine-protein kinase that functions in phosphatidylinositol
3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade,
and is involved in NF-kappa-B activation, mitogenic signaling, cell
proliferation, cell polarity, inflammatory response and maintenance of
long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in
macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate
MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation.
Required for insulin-dependent activation of AKT3, but may function as an
adapter rather than a direct activator. Upon insulin treatment may act as a
downstream effector of PI3K and contribute to the activation of translocation
of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in
adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5
independently of its kinase activity and can activate JUN promoter through
MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling
and activation of |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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