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簡要描述：磷酸化轉(zhuǎn)錄接頭蛋白EP300抗體別 名；CREBBP/EP300 inhibitory protein 1; Cyclic AMP responsive enhancer binding protein; E1A associated protein p300; E1A binding protein p300; EC 2.3.1.48; EP300; EP300: E1A binding protein p300; RB and P300 binding protein EID 1; Histone acetyltransfer
產(chǎn)品型號：GOY-01K2762廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：160產(chǎn)品分類
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磷酸化轉(zhuǎn)錄接頭蛋白EP300抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
磷酸化轉(zhuǎn)錄接頭蛋白EP300抗體 | phospho-Ep300 (Ser89) | GOY-01K2762 |
商品屬性：
英文名稱: phospho-Ep300 (Ser89)
中文名:磷酸化轉(zhuǎn)錄接頭蛋白EP300抗體
別 名；CREBBP/EP300
inhibitory protein 1; Cyclic AMP responsive enhancer binding protein; E1A
associated protein p300; E1A binding protein p300; EC 2.3.1.48; EP300; EP300:
E1A binding protein p300; RB and P300 binding protein EID 1; Histone
acetyltransferase p300; p300 HAT; Retinoblastoma protein associated protein.
交叉反應(yīng)；:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, GuineaPig
標(biāo)記:
Unconjugated
抗體來源；: Rabbit
抗體類型:
Polyclonal
免疫原: KLH
conjugated Synthesised phosphopeptide derived from human Ep300 around the
phosphorylation site of Ser89
蛋白細胞定位；: 細胞核,細胞漿
純化方法；: affinity
purified by Protein A
亞型: IgG
性狀: Liquid
濃度: 1mg/ml
儲存液: 0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；: Shipped
at 4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹:
Cyclic AMP-regulated gene expression frequently
involves a DNA element designated the cAMP-regulated enhancer (CRE). Many
transcription factors bind to this element, including the protein CREB which
is activated as a result of phosphorylation by protein kinase A. It has been
shown that protein kinase A-mediated CREB phosphorylation results in its
binding to a nuclear protein designated CBP (for CREB-binding protein). These
findings suggest that CBP has many of the properties expected of a CREB
co-activator. Another high molecular weight transcriptional adapter protein,
designated p300, is characterized by three cysteine- and histidine-rich
regions, of which the most carboxy terminal region specifically binds the
adenovirus E1A protein. p300 molecules lacking an intact E1A binding site
bypass E1A repression even in the presence of high concentrations of E1A.
Sequence analysis of CBP and p300 has revealed substantial homology, arguing
that these proteins are members of a conserved family of co-activators. |
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