歡迎來到上海谷研實業(yè)有限公司網站！
咨詢電話：18321818584歡迎來到上海谷研實業(yè)有限公司網站！咨詢電話：18321818584
簡要描述：磷酸化活化復制因子2重組兔單克隆抗體免 疫 原；KLH conjugated synthesised phosphopeptide derived from human ATF2 around the phosphorylation site of Thr71: TP(p-T)PT
產品型號：GOY-01K4403廠商性質：科研更新時間：2023-10-24 00:00:00訪 問 量：152產品分類
Product Category相關文章
Related Articles詳細介紹
磷酸化活化復制因子2重組兔單克隆抗體
產品名稱 | 英文名稱 | 貨號 |
磷酸化活化復制因子2重組兔單克隆抗體 | phospho-ATF2 (Thr71) | GOY-01K4403 |
商品屬性：
英文名稱: phospho-ATF2 (Thr71)
中文名:磷酸化活化復制因子2重組兔單克隆抗體
別 名；ATF2(T71); ATF2
(phospho T71 + T53); phospho-ATF2(Thr53)(mo); ATF2 (phospho T71); p-ATF2
(phospho T71); ATF2 (phospho Thr71); p-ATF2 (phospho Thr71); CREB 2; HB
16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response
Element Binding Protein 2; cAMP response element binding protein CRE BP1;
cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding
protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent
transcription factor ATF 2; Cyclic AMP-responsive; ATF2_HUMAN.
產品類型；磷酸化抗體 重組兔單抗
研究領域；細胞生物 轉錄調節(jié)因子 表觀遺傳學
抗體來源；Rabbit
克隆類型；Monoclonal
克 隆 號7B1
交叉反應；Human,
Mouse, Rat,
產品應用；WB=1:500-1000
IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；54kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthesised phosphopeptide derived from human ATF2 around the
phosphorylation site of Thr71: TP(p-T)PT
亞 型；IgG
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹:
ATF2 is a member of the ATF/CREB family of basic
region leucine zipper DNA binding proteins that regulates transcription by
binding to a consensus cAMP response element (CRE) in the promoter of various
viral and cellular genes. Many of these genes are important in cell growth
and differentiation, and in stress and immune responses. ATF2 is a nuclear
protein that binds DNA as a dimer and can form dimers with members of the
ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer
with cJun than as a homodimer. Several isoforms of ATF2 arise by differential
splicing. The stable native full length ATF2 is transcriptionally inactive as
a result of an inhibitory direct intramolecular interaction of its carboxy
terminal DNA binding domain with the amino terminal transactivation domain.
Following dimerization ATF2 becomes a short lived protein that undergoes
ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent
mechanism. Stimulation of the transcriptional activity of ATF2 occurs
following cellular stress induced by several genotoxic agents, inflammatory
cytokines, and UV irradiation. This activation requires phosphorylation of
two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase.
ATF2 is abundantly expressed in brain. Function: Transcriptional activator, probably constitutive,
which binds to the cAMP-responsive element (CRE) (consensus:
5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular
promoters. Interaction with JUN redirects JUN to bind to CRES preferentially
over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as
part of an ATF2/JUN complex. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
產品咨詢
電話
微信掃一掃
聯(lián)系人：銷售部
地址：上海市嘉定區(qū)澄瀏公路52號盛創(chuàng)企業(yè)
郵箱：3004918891@qq.com
手機：18321818584 / 15026555973