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簡(jiǎn)要描述：蛋白酶激活PA200抗體免 疫 原；KLH conjugated synthetic peptide derived from human PA200: 1561-1660/1843
產(chǎn)品型號(hào)：GOY-01K5991廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：154產(chǎn)品分類
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蛋白酶激活PA200抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
蛋白酶激活PA200抗體 | PA200 | GOY-01K5991 |
商品屬性：
英文名稱: PA200
中文名:蛋白酶激活PA200抗體
別 名；Proteasome
Activator Subunit 4; KIAA0077; PA200; Proteasome Activator 200 kDa; Proteasome
activator complex subunit 4; Proteasome activator PA200; PSME 4; PSME4;
PSME4_HUMAN.
研究領(lǐng)域；細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 泛素
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；IHC-P=1:100-500
IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；211kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human PA200: 1561-1660/1843
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human, therapeutic
or diagnostic applications.
產(chǎn)品介紹:
PA200 is a 1,843 amino acid nuclear protein that
contains six HEAT (Huntington, Elongation Factor 3, PR65/A, TOR) repeats,
which are conserved residues that form the hydrophobic domain core and are
usually found in proteins that are involved in intracellular transport.
Existing as a homodimer, PA200 interacts with the 20S and 26S proteasomes and
activates proteasomal cleavage of peptides in an energy-independent manner.
PA200 and proteasomes function together within cells and respond to specific
radiation-induced damage independent of the stage of cell cycle arrest.
Broadly expressed, PA200 may also be involved in spermatogenesis and in DNA
repair double-strand breaks (DSBs). Four isoforms of PA200 exists due to alternative
splicing events. Associated component of the proteasome that
specifically recognizes acetylated histones and promotes ATP- and
ubiquitin-independent degradation of core histones during spermatogenesis and
DNA damage response. Recognizes and binds acetylated histones via its
bromodomain-like (BRDL) region and activates the proteasome by opening the
gated channel for substrate entry. Binds to the core proteasome via its
C-terminus, which occupies the same binding sites as the proteasomal ATPases,
opening the closed structure of the proteasome via an active gating
mechanism. Component of the spermatoproteasome, a form of the proteasome
specifically found in testis: binds to acetylated histones and promotes
degradation of histones, thereby participating actively to the exchange of
histones during spermatogenesis. Also involved in DNA damage response in
somatic cells, by promoting degradation of histones following DNA
double-strand breaks. Subunit: Homodimer. Interacts with the 20S and 26S
proteasomes. Component of the spermatoproteasome, a form of the proteasome
specifically found in testis. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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