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簡要描述：p400蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human p400: 1051-1250/3159
產(chǎn)品型號：GOY-01K4160廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：164產(chǎn)品分類
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p400蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
p400蛋白抗體 | p400 | GOY-01K4160 |
商品屬性：
英文名稱: p400
中文名:p400蛋白抗體
別 名；CAG repeat
protein 32; CAGH32; DKFZP434I225; Domino homolog; E1A binding protein p400; EP
400; EP400; FLJ42018; FLJ45115; hDomino; KIAA1498; KIAA1818; p400 kDa SWI2/SNF2
related protein; P400 SWI2/SNF2-related protein; TNRC12; Trinucleotide repeat
containing 12; Trinucleotide repeat containing gene 12 protein; EP400_HUMAN.
研究領(lǐng)域；腫瘤 細胞生物 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；344kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human p400: 1051-1250/3159
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
NuAR is a multi-protein histone acetyltransferase
complex that functions to acetylate the nucleosomal Histones H4 and H2A,
thereby activating transcription of select target genes. p400, also known as
EP400 (E1A binding protein p400) or mDomino, localizes to the nucleus and is
a component of the NuAR complex. Expressed in brain, liver, thymus, lung,
spleen, colon and kidney, p400 regulates the transcriptional activity of
proteins such as MZF-1 and contributes to the ATPase and helicase activities
of NuA4. p400 is a SWI2/ SNF2-related protein that can interact with the
adenovirus oncoprotein E1A, thus activating the proapoptotic activity of E1A.
The ability of p400 to regulate transcriptional and apoptotic activity
suggests that the NuAR complex may be a crucial component of cell proliferation,
transformation and, possibly, carcinogenesis. Five isoforms of p400 exist due
to alternative splicing events. Component of the NuA4 histone acetyltransferase
complex which is involved in transcriptional activation of select genes
principally by acetylation of nucleosomal histones H4 and H2A. This
modification may both alter nucleosome - DNA interactions and promote
interaction of the modified histones with other proteins which positively
regulate transcription. May be required for transcriptional activation of
E2F1 and MYC target genes during cellular proliferation. The NuA4 complex
ATPase and helicase activities seem to be, at least in part, contributed by
the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42
transcription activity. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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