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簡要描述：中性鞘磷脂2抗體免 疫 原；KLH conjugated synthetic peptide derived from human NSMase2: 511-610/655
產(chǎn)品型號：GOY-01K2270廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：147產(chǎn)品分類
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中性鞘磷脂2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
中性鞘磷脂2抗體 | NSMase2 | GOY-01K2270 |
商品屬性：
英文名稱: NSMase2
中文名:中性鞘磷脂2抗體
別 名；N-SMase2; Cca1;
neutral sphingomyelinase 2; Confluent 3Y1 cell-associated protein 1; Neutral
sphingomyelinase 2; Neutral sphingomyelinase II; NSMA2_HUMAN; nSMase-2;
nSMase2; Smpd3; Sphingomyelin phosphodiesterase 3.
研究領(lǐng)域；細胞生物 神經(jīng)生物學(xué) 脂蛋白
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；71kDa
細胞定位；細胞漿 細胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human NSMase2: 511-610/655
亞 型；IgG
純化方法；affinity
purified by Protein A
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
N-SMase2 (neutral sphingomyelinase 2), also known
as NSMASE2 or SMPD3 (sphingomyelin phosphodiesterase 3), is a ubiquitously
expressed 655 amino acid member of the magnesium-dependent phosphohydrolase
protein family. Localized to the membrane of the Golgi apparatus, N-SMase2
functions to catalyze the hydrolysis of sphingomyelin to form ceramide and
phosphocholine—two proteins that mediate cell
growth arrest and apoptosis. N-SMase2 is enzymatically activated by
unsaturated fatty acids and phosphatidylserine and, through regulation of
ceramide synthesis, is involved in growth suppression and postnatal
development. Expression of N-SMase2 is upregulated during the G0/G1 phases of
the cell cycle and optimal N-SMase2 activity occurs at a slightly basic pH of
7.5. N-SMase2 deficiency is the cause of chondrodysplasia, a genetic disorder
characterized by impaired bone growth that leads to short stature, bowlegs
and underdeveloped joints. Function: Catalyzes the hydrolysis of sphingomyelin to form
ceramide and phosphocholine. Ceramide mediates numerous cellular functions,
such as apoptosis and growth arrest, and is capable of regulating these 2
cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates
the cell cycle by acting as a growth suppressor in confluent cells. Probably
acts as a regulator of postnatal development and participates in bone and
dentin mineralization. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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