簡要描述:NOC2家族樣蛋白抗體免 疫 原;KLH conjugated synthetic peptide derived from human NOC2L: 251-350/749
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NOC2家族樣蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
NOC2家族樣蛋白抗體 | NOC2L | GOY-01K1784 |
商品屬性:
英文名稱: NOC2L
中文名:NOC2家族樣蛋白抗體
別 名;NIR; NOC2 like;
Novel INHAT (inhibitor of histone acetyltransferase) repressor; Nucleolar
complex associated 2 homolog (S. cerevisiae); Protein NOC2 homolog;
NOC2L_HUMAN.
研究領(lǐng)域;細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué)
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;85kDa
細(xì)胞定位;細(xì)胞核 細(xì)胞漿
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human NOC2L: 251-350/749
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
NOC2L is a transcriptional corepressor with
inhibitor of histone acetyltransferase (INHAT) activity. NOC2L or NIR (Novel
INHAT Repressor) is ubiquitously expressed throughout embryonic development
and adulthood. It is a potent transcriptional corepressor that is not blocked
by histone deacetylase inhibitors and is capable of silencing both basal and
activator-driven transcription. NOC2L directly binds to nucleosomes and core
histones and prevents acetylation by histone acetyltransferases, thus acting
as a bona fide INHAT. Acts as an inhibitor of histone acetyltransferase
activity; prevents acetylation of all core histones by the EP300/p300 histone
acetyltransferase at p53/TP53-regulated target promoters in a histone
deacetylases (HDAC)-independent manner. Acts as a transcription corepressor
of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter.
Involved in the regulation of p53/TP53-dependent apoptosis. Associates
together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. Subunit: Interacts with p53/TP53. Interacts (via the N- and
C-terminus domains) with AURKB (via the middle kinase domain). Interacts with
TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3
(via N-terminus and non-acetylated form preferentially). Associates with core
histones and nucleosomes. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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