簡要描述:核酸內(nèi)切酶8樣蛋白2抗體免 疫 原;KLH conjugated synthetic peptide derived from human NEIL2: 101-200/332
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核酸內(nèi)切酶8樣蛋白2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
核酸內(nèi)切酶8樣蛋白2抗體 | NEIL2 | GOY-01K5895 |
商品屬性:
英文名稱: NEIL2
中文名:核酸內(nèi)切酶8樣蛋白2抗體
別 名;NEIL2 belongs to
a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These
glycosylases initiate the first step in base excision repair by cleaving bases
damaged by reactive oxygen species and introducing a DNA strand break via the
associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by
OMIM, Mar 2008]
研究領(lǐng)域;細(xì)胞生物 表觀遺傳學(xué)
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;30, 37kDa
細(xì)胞定位;細(xì)胞核
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human NEIL2: 101-200/332
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
NEIL2 belongs to a class of DNA glycosylases
homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first
step in base excision repair by cleaving bases damaged by reactive oxygen
species and introducing a DNA strand break via the associated lyase reaction
(Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008] Involved in base excision repair of DNA damaged by
oxidation or by mutagenic agents. Has DNA glycosylase activity towards
5-hydroxyuracil and other oxidized derivatives of cytosine with a preference
for mismatched double stranded DNA (DNA bubbles). Has low or no DNA
glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine
and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and
introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta
elimination to generate a single-strand break at the site of the removed base
with both 3'- and 5'-phosphates. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達到1:32000,由蛋白抗原制備的多抗,保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時,也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺,能為客戶提供各種類型的重組抗體表達服務(wù),包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達,抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù),如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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