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簡要描述：核受體共激活因子NCOA62抗體免 疫 原；KLH conjugated synthetic peptide derived from human NCOA62: 51-150/536
產(chǎn)品型號(hào)：GOY-01K5858廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：152產(chǎn)品分類
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核受體共激活因子NCOA62抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
核受體共激活因子NCOA62抗體 | NCOA62 | GOY-01K5858 |
商品屬性：
英文名稱: NCOA62
中文名:核受體共激活因子NCOA62抗體
別 名；Bx 42; Bx42;
Homolog of Drosophila BX42; MGC119379; NCOA 62; Nuclear protein SkiP; Nuclear
receptor coactivator 62 kD; Nuclear receptor coactivator NCoA 62; Nuclear
receptor coactivator NCoA62; Prp 45; Prp45; PRPF 45; PRPF45; Ski interacting
protein; SKIIP; SKIP; SNW 1; SNW1_HUMAN; SNW domain containing 1; SNW domain
containing protein 1; SNW1; SNW1 protein.
研究領(lǐng)域；腫瘤 細(xì)胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；61kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human NCOA62: 51-150/536
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M TBS(pH7.4)
with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
This gene, a member of the SNW gene family,
encodes a coactivator that enhances transcription from some Pol II promoters.
This coactivator can bind to the ligand-binding domain of the vitamin D
receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-,
estrogen-, and glucocorticoid-mediated gene expression. It can also function
as a splicing factor by interacting with poly(A)-binding protein 2 to
directly control the expression of muscle-specific genes at the
transcriptional level. Finally, the protein may be involved in oncogenesis
since it interacts with a region of SKI oncoproteins that is required for
transforming activity. [provided by RefSeq, Jul 2008] Involved in transcriptional regulation. Modulates
TGF-beta-mediated transcription via association with SMAD proteins,
MYOD1-mediated transcription via association with PABPN1, RB1-mediated
transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D
receptor (VDR)-dependent gene transcription in a cell line-specific manner
probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated
transcriptional activation. Binds to multimerized forms of Notch
intracellular domain (NICD) and is proposed to recruit transcriptional
coactivators such as MAML1 to form an intermediate preactivation complex
which associates with DNA-bound CBF-1/RBPJ to form a transcriptional
activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to
be involved in transcriptional activation by EBV EBNA2 of
CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR
RNA complexes and is involved in Tat transcription by recruitment of MYC,
MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in
pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA;
the function probbaly involves the recruitment of U2AF2 to the mRNA. Is
proposed to recruit PPIL1 to the spliceosome. May be involved in
cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates
with both the 3'end of the CCND1 gene and its mRNA. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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