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簡要描述：MRVI1蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human MRVI1: 51-150/885
產(chǎn)品型號：GOY-01K5442廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：149產(chǎn)品分類
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MRVI1蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
MRVI1蛋白抗體 | MRVI1 | GOY-01K5442 |
商品屬性：
英文名稱: MRVI1
中文名:MRVI1蛋白抗體
別 名；Inositol
1,4,5-triphosphate receptor-associated cGMP kinase substrate; Inositol
145-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase
substrate; IRAG; JAW1-related protein MRVI1; JAW1L; Murine retrovirus
integration site 1 homolog.
研究領(lǐng)域；細(xì)胞生物 信號轉(zhuǎn)導(dǎo)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；IHC-P=1:100-500
IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；96kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human MRVI1: 51-150/885
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M TBS(pH7.4)
with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
This gene is similar to a putative mouse tumor
suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related
virus (MRV). The encoded protein, which is found in the membrane of the
endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein
whose expression is down-regulated during lymphoid differentiation. This
protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as
a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV
integration at Mrvi1 induces myeloid leukemia by altering the expression of a
gene important for myeloid cell growth and/or differentiation, and thus this
gene may function as a myeloid leukemia tumor suppressor gene. Several
alternatively spliced transcript variants encoding different isoforms have
been found for this gene, and alternative translation start sites, including
a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011] This gene is similar to a putative mouse tumor
suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related
virus (MRV). The encoded protein, which is found in the membrane of the
endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein
whose expression is downregulated during lymphoid differentiation. Studies in
mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by
altering the expression of a gene important for myeloid cell growth and/or
differentiation, and thus this gene may function as a myeloid leukemia tumor
suppressor gene. Several alternatively spliced transcript variants encoding
different isoforms have been found for this gene, few of which initiate
translation at a non-AUG (CUG) start site. Subunit: Part of cGMP kinase signaling complex at least
composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and
ITPR1 (By similarity). Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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