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簡(jiǎn)要描述：癌/睪丸抗原128抗體免 疫 原；KLH conjugated synthetic peptide derived from human MAEL/CT128: 201-300/434
產(chǎn)品型號(hào)：GOY-01K0154廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：148產(chǎn)品分類
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癌/睪丸抗原128抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
癌/睪丸抗原128抗體 | MAEL/CT128 | GOY-01K0154 |
商品屬性：
英文名稱: MAEL/CT128
中文名:癌/睪丸抗原128抗體
別 名；cancer/testis
antigen 128; CT128; FLJ14904; mael; MAEL_HUMAN; maelstrom homolog (Drosophila);
Maelstrom homolog; OTTHUMP00000032344; Protein maelstrom homolog;
RP11-102C16.1.
研究領(lǐng)域；腫瘤 細(xì)胞生物 表觀遺傳學(xué)
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；49kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human MAEL/CT128: 201-300/434
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Mael is a 434 amino acid protein that localizes to
both the nucleus and the cytoplasm and contains one HMG box DNA-binding domain.
Expressed specifically in testicular tissue, Mael interacts with Ini1, mSin3B
and VASA and plays an essential role in spermatogenesis, specifically by
repressing and, ultimately, preventing the mobilization of transposable
elements (a process that is crucial for germline integrity). Multiple
isoforms of Mael exist due to alternative splicing events. The gene encoding
Mael maps to human chromosome 1, which spans 260 million base pairs, contains
over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1
houses a large number of disease-associated genes, including those that are
involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher
syndrome. Aberrations in chromosome 1 are found in a variety of cancers,
including head and neck cancer, malignant melanoma and multiple myeloma. Plays a central role during spermatogenesis by
repressing transposable elements and prevent their mobilization, which is
essential for the germline integrity. Acts via the piRNA metabolic process,
which mediates the repression of transposable elements during meiosis by
forming complexes composed of piRNAs and Piwi proteins and govern the
methylation and subsequent repression of transposons. Its association with
piP-bodies suggests a participation in the secondary piRNAs metabolic
process. Required for localization of germ-cell factors to the meiotic nuage. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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