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角質細胞生長因子調節(jié)蛋白2抗體
產品名稱 | 英文名稱 | 貨號 |
角質細胞生長因子調節(jié)蛋白2抗體 | KRG2/DDX11 | GOY-01K2169 |
商品屬性：
英文名稱: KRG2/DDX11
中文名:角質細胞生長因子調節(jié)蛋白2抗體
別 名；CHL1; CHL1
related helicase gene 1; CHL1-like helicase homolog; CHL1-related protein 1; CHLR1;
Ddx11; DDX11_HUMAN; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11; DEAD/H box
protein 11; hCHLR1; Keratinocyte growth factor regulated gene 2 protein;
Keratinocyte growth factor-regulated gene 2 protein; KRG 2; KRG-2; KRG2;
Probable ATP dependent RNA helicase DDX11; Probable ATP-dependent RNA helicase
DDX11.
研究領域；細胞生物 細胞周期蛋白 細胞分化 b-淋巴細胞 表觀遺傳學
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；Human,
Mouse, Rat,
產品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；108kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KRG2/DDX11: 251-350/970
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
DEAD box proteins, characterized by the conserved
motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated
in a number of cellular processes involving alteration of RNA secondary
structure such as translation initiation, nuclear and mitochondrial splicing,
and ribosome and spliceosome assembly. Based on their distribution patterns,
some members of this family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene encodes a DEAD
box protein, which is an enzyme that possesses both ATPase and DNA helicase
activities. This gene is a homolog of the yeast CHL1 gene, and may function
to maintain chromosome transmission fidelity and genome stability.
Alternative splicing results in multiple transcript variants encoding
distinct isoforms. [provided by RefSeq, Jul 2008] DNA-dependent ATPase and ATP-dependent DNA
helicase that participates in various functions in genomic stability,
including DNA replication, DNA repair and heterochromatin organization as
well as in ribosomal RNA synthesis. Its double-stranded DNA helicase activity
requires either a minimal 5-single-stranded tail length of approximately 15
nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of
a partial duplex DNA structure for helicase loading and translocation along
DNA in a 5 to 3 direction . The helicase activity is capable of displacing
duplex regions up to 100 bp, which can be extended up to 500 bp by the
replication protein A (RPA) or the cohesion CTF18-replication factor C
(Ctf18-RFC) complex activities . Shows also ATPase- and helicase activities
on substrates that mimic key DNA intermediates of replication, repair and
homologous recombination reactions, including forked duplex, anti-parallel
G-quadruplex and three-stranded D-loop DNA molecules. Plays a role in DNA
double-strand break (DSB) repair at the DNA replication fork during DNA
replication recovery from DNA damage. Recruited with TIMELESS factor upon
DNA-replication stress response at DNA replication fork to preserve
replication fork progression, and hence ensure DNA replication fidelity.
Cooperates also with TIMELESS factor during DNA replication to regulate
proper sister chromatid cohesion and mitotic chromosome segregation.
Stimulates 5-single-stranded DNA flap endonuclease activity of FEN1 in an
ATP- and helicase-independent manner; and hence it may contribute in Okazaki
fragment processing at DNA replication fork during lagging strand DNA
synthesis. Its ability to function at DNA replication fork is modulated by
its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA
DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and
binding to DNA replicating regions. Plays also a role in heterochromatin
organization. Involved in rRNA transcription activation through binding to
active hypomethylated rDNA gene loci by recruiting UBTF and the RNA
polymerase Pol I transcriptional machinery. Plays a role in embryonic
development and prevention of aneuploidy (By similarity). Involved in
melanoma cell proliferation and survival. Associates with chromatin at DNA
replication fork regions. Binds to single- and double-stranded DNAs. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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