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組蛋白賴氨酸N-甲基轉移酶2B抗體
產品名稱 | 英文名稱 | 貨號 |
組蛋白賴氨酸N-甲基轉移酶2B抗體 | KMT2B | GOY-01K1313 |
商品屬性：
英文名稱: KMT2B
中文名:組蛋白賴氨酸N-甲基轉移酶2B抗體
別 名；Histone-lysine
N-methyltransferase 2B; HRX2; KIAA0304 gene product; KMT2B; KMT2B_HUMAN; Likely
ortholog of mouse WW domain binding protein 7; Lysine N-methyltransferase 2B;
mixed lineage leukemia 4; Mixed lineage leukemia gene homolog 2 protein; MLL2;
myeloid lymphoid leukemia 4; Myeloid lymphoid or mixed lineage leukemia protein
4; Myeloid/lymphoid or mixed-lineage leukemia protein 4; Trithorax homolog 2;
trithorax homologue 2; TRX2; WBP-7; WBP7; WW domain-binding protein 7.
研究領域；細胞生物 轉錄調節(jié)因子 表觀遺傳學
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Dog, Cow, Horse, )
產品應用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；293kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KMT2B: 501-600/2715
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
This gene encodes a protein which contains
multiple domains including a CXXC zinc finger, three PHD zinc fingers, two
FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and
trithorax) domain. The SET domain is a conserved C-terminal domain that
characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene
is ubiquitously expressed in adult tissues. It is also amplified in solid
tumor cell lines, and may be involved in human cancer. Two alternatively
spliced transcript variants encoding distinct isoforms have been reported for
this gene, however, the full length nature of the shorter transcript is not
known. [provided by RefSeq, Jul 2008] Function: Histone methyltransferase. Methylates 'Lys-4' of
histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic
transcriptional activation. Plays a central role in beta-globin locus
transcription regulation by being recruited by NFE2. Plays an important role
in controlling bulk H3K4me during oocyte growth and preimplantation
development. Required during the transcriptionally active period of oocyte
growth for the establishment and/or maintenance of bulk H3K4 trimethylation
(H3K4me3), global transcriptional silencing that preceeds resumption of
meiosis, oocyte survival and normal zygotic genome activation. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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