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簡要描述：賴氨酸N甲基轉移酶1D/EHMT1抗體免 疫 原；KLH conjugated synthetic peptide derived from human KMT1D: 251-350/1298
產品型號：GOY-01K0438廠商性質：科研更新時間：2023-10-24 00:00:00訪 問 量：145產品分類
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賴氨酸N甲基轉移酶1D/EHMT1抗體
產品名稱 | 英文名稱 | 貨號 |
賴氨酸N甲基轉移酶1D/EHMT1抗體 | KMT1D | GOY-01K0438 |
商品屬性：
英文名稱: KMT1D
中文名:賴氨酸N甲基轉移酶1D/EHMT1抗體
別 名；bA188C12.1;
DKFZp667M072; EHMT 1; EHMT1; EHMT1_HUMAN; Eu-HMTase1; Eu HMTase1; Euchromatic
histone lysine N methyltransferase 1; Euchromatic histone methyltransferase 1;
Euchromatic histone-lysine N-methyltransferase 1; EUHMTASE1; FLJ12879; FP13812;
G9a like protein 1; G9a like protein; G9a-like protein 1; GLP 1; GLP; GLP1; H3
K9 HMTase 5; H3-K9-HMTase 5; Histone H3 K9 methyltransferase 5; Histone H3-K9
methyltransferase 5; Histone lysine N methyltransferase H3 lysine 9 specific 5;
Histone-lysine N-methyltransferase EHMT1; KIAA1876; Lysine N methyltransferase
1D; Lysine N-methyltransferase 1D; RP11 188C12.1.
研究領域；細胞生物 細胞周期蛋白 膠原蛋白 表觀遺傳學
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Cow, Rabbit, )
產品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；141kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KMT1D: 251-350/1298
亞 型；IgG
純化方法；affinity purified
by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
The protein encoded by this gene is a histone
methyltransferase that is part of the E2F6 complex, which represses
transcription. The encoded protein methylates the Lys-9 position of histone
H3, which tags it for transcriptional repression. This protein may be
involved in the silencing of MYC- and E2F-responsive genes and therefore
could play a role in the G0/G1 cell cycle transition. Defects in this gene
are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome).
Two transcript variants encoding different isoforms have been found for this
gene. [provided by RefSeq, Mar 2009] Histone methyltransferase that specifically mono-
and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in
euchromatin. H3K9me represents a specific tag for epigenetic transcriptional
repression by recruiting HP1 proteins to methylated histones. Also weakly
methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA
methylation, the histone methyltransferase activity is not required for DNA
methylation, suggesting that these 2 activities function independently.
Probably targeted to histone H3 by different DNA-binding proteins like E2F6,
MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of
MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell
cycle. In addition to the histone methyltransferase activity, also methylates
non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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