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簡(jiǎn)要描述：鉀通道四聚體結(jié)構(gòu)域蛋白11抗體免 疫 原；KLH conjugated synthetic peptide derived from human KCTD11: 31-130/232
產(chǎn)品型號(hào)：GOY-01K2246廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：130產(chǎn)品分類
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鉀通道四聚體結(jié)構(gòu)域蛋白11抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
鉀通道四聚體結(jié)構(gòu)域蛋白11抗體 | KCTD11 | GOY-01K2246 |
商品屬性：
英文名稱: KCTD11
中文名:鉀通道四聚體結(jié)構(gòu)域蛋白11抗體
別 名；C17orf36; MGC
129844; Potassium channel tetramerisation domain containing 11; REN; Retinoic
acid EGF NGF induced gene protein; C 17 orf 36; KCD11_HUMAN.
研究領(lǐng)域；腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 通道蛋白 跨膜蛋白
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；26kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿 細(xì)胞外基質(zhì) 分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KCTD11: 31-130/232
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The KCTD11 gene encodes a protein that has been
identified as a suppressor of Hedgehog signaling. Its inactivation might lead
to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma.
Plays a role as a marker and a regulator of neuronal differentiation;
Up-regulated by a variety of neurogenic signals, such as retinoic acid,
epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis,
growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B.
Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity
of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on
cell proliferation and differentiation by affecting the nuclear transfer of
transcrition factor GLI1, thus maintaining cerebellar granule cells in
undifferentiated state. Plays a role as a marker and a regulator of
neuronal differentiation; Up-regulated by a variety of neurogenic signals,
such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth
factor. Induces apoptosis, growth arrest and the expression of
cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor
and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as
an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal
degradation. Functions as antagonist of the Hedgehog pathway on cell
proliferation and differentiation by affecting the nuclear transfer of
transcrition factor GLI1, thus maintaining cerebellar granule cells in
undifferentiated state, this effect probably occurs via HDAC1
down-regulation, keeping GLI1 acetylated and inactive. When knock-down,
Hedgehog antagonism is impaired and proliferation of granule cells is
sustained. Activates the caspase cascade. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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