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簡要描述：電壓門控鉀通道亞基Kv7.4抗體免 疫 原；KLH conjugated synthetic peptide derived from human KCNQ4: 601-695/695
產(chǎn)品型號：GOY-01K5175廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：133產(chǎn)品分類
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電壓門控鉀通道亞基Kv7.4抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
電壓門控鉀通道亞基Kv7.4抗體 | KCNQ4 | GOY-01K5175 |
商品屬性：
英文名稱: KCNQ4
中文名:電壓門控鉀通道亞基Kv7.4抗體
別 名；DFNA 2; DFNA2;
KCNQ 4; Kcnq4; KCNQ4_HUMAN; KQT like 4; KQT-like 4; KV7.4; Potassium channel
KQT like 4; Potassium channel subunit alpha KvLQT4; Potassium voltage gated
channel KQT like protein 4; Potassium voltage gated channel KQT like subfamily
member 4; Potassium voltage gated channel subfamily KQT member 4; Potassium
voltage-gated channel subfamily KQT member 4; Voltage gated potassium channel
subunit Kv7.4; Voltage-gated potassium channel subunit Kv7.4.
研究領(lǐng)域；細胞生物 神經(jīng)生物學(xué) 通道蛋白
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；77kDa
細胞定位；細胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KCNQ4: 601-695/695
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The protein encoded by this gene forms a potassium
channel that is thought to play a critical role in the regulation of neuronal
excitability, particularly in sensory cells of the cochlea. The current
generated by this channel is inhibited by M1 muscarinic acetylcholine
receptors and activated by retigabine, a novel anti-convulsant drug. The
encoded protein can form a homomultimeric potassium channel or possibly a
heteromultimeric channel in association with the protein encoded by the KCNQ3
gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness
type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two
transcript variants encoding different isoforms have been found for this
gene. [provided by RefSeq, Jul 2008] Probably important in the regulation of neuronal
excitability. May underlie a potassium current involved in regulating the
excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by
linopirdin, XE991 and bepridil, whereas clofilium is without significant
effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in
CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic
receptors. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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