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簡要描述：A型流感病毒H5N1神經(jīng)氨酸酶1抗體免 疫 原；KLH conjugated synthetic peptide derived from Influenza A H5N1 Neuraminidase 1: 301-400/450
產(chǎn)品型號：GOY-01K2542廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：155產(chǎn)品分類
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A型流感病毒H5N1神經(jīng)氨酸酶1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
A型流感病毒H5N1神經(jīng)氨酸酶1抗體 | Influenza A Neuraminidase 1 | GOY-01K2542 |
商品屬性：
英文名稱: Influenza A Neuraminidase 1
中文名:A型流感病毒H5N1神經(jīng)氨酸酶1抗體
別 名；NRAM_I97A1; H5N1
Neuraminidase 1.
研究領(lǐng)域；細菌及病毒
抗體來源；Rabbit
克隆類型；Polyclonal
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；49kDa
細胞定位；細胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from Influenza A H5N1 Neuraminidase 1:
301-400/450
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Influenza A virus is a major public health threat,
killing more than 30,000 people per year in the USA (1). Novel influenza
virus strains emerge periodically to which humans have little or no immunity,
resulting in devastating pandemics. Influenza A can exist in a variety of
animals; however it is in birds that all subtypes can be found (2). These
subtypes are classified based on the combination of the virus coat
glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During
1997, an H5N1 avian influenza virus was determined to be the cause of death
in 6 of 18 infected patients in Hong Kong (3). There was some evidence of
human to human spread of this virus, but it is thought that the transmission
efficiency was fairly low (4). Although it has been known that cleavage site
and glycosylation patterns of the HA protein play important roles in
determining the pathogenicity of H5 avian influenza viruses, it has only
recently been shown that an additional glycosylation site within the globular
head of the NA protein also contributes to the high virulence of the H5N1 virus
(5). Function: Catalyzes the removal of terminal sialic acid
residues from viral and cellular glycoconjugates. Cleaves off the terminal
sialic acids on the glycosylated HA during virus budding to facilitate virus
release. Additionally helps virus spread through the circulation by further
removing sialic acids from the cell surface. These cleavages prevent
self-aggregation and ensure the efficient spread of the progeny virus from
cell to cell. Otherwise, infection would be limited to one round of replication.
Described as a receptor-destroying enzyme because it cleaves a terminal
sialic acid from the cellular receptors. May facilitate viral invasion of the
upper airways by cleaving the sialic acid moities on the mucin of the airway
epithelial cells. Likely to plays a role in the budding process through its
association with lipid rafts during intracellular transport. May additionally
display a raft-association independent effect on budding. Plays a role in the
determination of host range restriction on replication and virulence.
Sialidase activity in late endosome/lysosome traffic seems to enhance virus
replication. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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