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簡要描述：白細胞介素27β抗體免 疫 原；KLH conjugated synthetic peptide derived from human EBI3/IL-27beta: 121-229/229
產(chǎn)品型號：GOY-01K1128廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：147產(chǎn)品分類
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白細胞介素27β抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
白細胞介素27β抗體 | IL-27beta | GOY-01K1128 |
商品屬性：
英文名稱: IL-27beta
中文名:白細胞介素27β抗體
別 名；cytokine
receptor; EBI3; EBV induced gene 3 protein; EBV-induced gene 3 protein; Epstein
Barr virus induced 3; Epstein Barr virus induced gene 3; Epstein Barr virus
induced gene 3 protein; Epstein-Barr virus-induced gene 3 protein; IL 27
subunit beta; IL 27B; IL-27 subunit beta; IL-27B; IL27 subunit; IL27 subunit
beta; IL27B; IL27B_HUMAN; interleukin 27 subunit beta; Interleukin-27 subunit
beta.
研究領(lǐng)域；細胞生物 免疫學 細菌及病毒
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；23, 50kDa
細胞定位；細胞漿 分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human EBI3/IL-27beta: 121-229/229
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Epstein-Barr virus-induced gene 3 (Ebi3) is a
widely expressed homolog to the interleukin IL-12 p40 subunit protein that
forms a heterodimer with either IL-12 p35 or an IL-12 p35 homolog, p28, to
create a new cytokine (IL-27). Ebi3 may function to antagonize IL-12 and to
inhibit the development of a Th1 immune response. Ebi3 is strongly expressed
in Hodgkin and Reed-Sternberg cells, independently of the EBV status of the
tumor cells. Ebi2 is expressed in B-lymphocytes and lymphoid tissues and may
function in the modulation of the immune system. Out of the nine genes that
are induced by the Epstein-Barr virus, Ebi2 exhibits the highest levels of
up-regulation. In addition, Ebi2 may play a role mediating normal lymphocyte
functions. Cytokine with pro- and anti-inflammatory
properties, that can regulate T-helper cell development, suppress T-cell
proliferation, stimulate cytotoxic T-cell activity, induce isotype switching
in B-cells, and that has diverse effects on innate immune cells. Among its
target cells are CD4 T-helper cells which can differentiate in type 1
effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper
T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4
T-cells. It also strongly synergizes with IL-12 to trigger
interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the
cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor
activity as well as its antiangiogenic activity with activation of production
of antiangiogenic chemokines. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學及檢測服務(wù):
我公司也為客戶提供單項免疫學和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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