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簡要描述：白細(xì)胞介素12p40抗體免 疫 原；KLH conjugated synthetic peptide derived from human IL12 p40: 201-300/328
產(chǎn)品型號：GOY-01K2596廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：156產(chǎn)品分類
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白細(xì)胞介素12p40抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
白細(xì)胞介素12p40抗體 | IL12 p40 | GOY-01K2596 |
商品屬性：
英文名稱: IL12 p40
中文名:白細(xì)胞介素12p40抗體
別 名；CLMF; CLMF p40;
CLMF2; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL 12 subunit
p40; IL 12B; IL-12 subunit p40; IL-12B; IL12 subunit p40; IL12B; IL12B_HUMAN;
interleukin 12 beta chain; Interleukin 12 p40; Interleukin 12 subunit beta;
Interleukin 12B; Interleukin-12 subunit beta; natural killer cell stimulatory
factor 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF2; p40.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；Rat, (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；46kDa
細(xì)胞定位；分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human IL12 p40: 201-300/328
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
This gene encodes a subunit of interleukin 12, a
cytokine that acts on T and natural killer cells, and has a broad array of
biological activities. Interleukin 12 is a disulfide-linked heterodimer
composed of the 40 kD cytokine receptor like subunit encoded by this gene,
and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated
macrophages that serve as an essential inducer of Th1 cells development. This
cytokine has been found to be important for sustaining a sufficient number of
memory/effector Th1 cells to mediate long-term protection to an intracellular
pathogen. Overexpression of this gene was observed in the central nervous
system of patients with multiple sclerosis (MS), suggesting a role of this
cytokine in the pathogenesis of the disease. The promoter polymorphism of
this gene has been reported to be associated with the severity of atopic and
non-atopic asthma in children. [provided by RefSeq, Jul 2008] Cytokine that can act as a growth factor for
activated T and NK cells, enhance the lytic activity of
NK/lymphokine-activated killer cells, and stimulate the production of
IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin,
an heterodimeric cytokine which functions in innate and adaptive immunity.
IL-23 may constitute with IL-17 an acute response to infection in peripheral
tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1
and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather
than naive T-cells and promotes production of proinflammatory cytokines.
IL-23 induces autoimmune inflammation and thus may be responsible for
autoimmune inflammatory diseases and may be important for tumorigenesis. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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