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簡要描述：黑色素瘤分化相關(guān)蛋白5抗體注意事項；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品型號：GOY-01K2607廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：166產(chǎn)品分類
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黑色素瘤分化相關(guān)蛋白5抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
黑色素瘤分化相關(guān)蛋白5抗體 | IFIH1 | GOY-01K2607 |
商品屬性：
英文名稱: IFIH1
中文名:黑色素瘤分化相關(guān)蛋白5抗體
別 名；CADM-140
autoantigen; Clinically amyopathic dermatomyositis autoantigen 140 kDa; DEAD/H
(Asp Glu Ala Asp/His) box polypeptide; DEAD/H box polypeptide; Helicard;
Helicase with 2 CARD domains; Hlcd; IDDM 19; IDDM19; IFIH 1; IFIH1_HUMAN;
Interferon induced helicase C domain containing protein 1; interferon induced
with helicase C domain 1; Interferon induced with helicase C domain protein 1;
Interferon-induced helicase C domain-containing protein 1; Interferon-induced
with helicase C domain protein 1; MDA 5; MDA-5; MDA5; Melanoma differentiation
associated protein 5; Melanoma differentiation-associated gene 5; Melanoma
differentiation-associated protein 5; MGC133047; Murabutide down regulated
protein; Murabutide down-regulated protein; RH 116; RH116; RIG I like receptor
2; RLR 2; RNA helicase DEAD box protein 116; RNA helicase-DEAD box protein 116.
研究領(lǐng)域；細胞生物 糖尿病 細胞分化 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；117kDa
細胞定位；細胞核 細胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human IFIH1: 901-1025/1025
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
DEAD box proteins, characterized by the conserved
motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated
in a number of cellular processes involving alteration of RNA secondary
structure such as translation initiation, nuclear and mitochondrial splicing,
and ribosome and spliceosome assembly. Based on their distribution patterns,
some members of this family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene encodes a DEAD
box protein that is upregulated in response to treatment with beta-interferon
and a protein kinase C-activating compound, mezerein. Irreversible reprogramming
of melanomas can be achieved by treatment with both these agents; treatment
with either agent alone only achieves reversible differentiation. Genetic
variation in this gene is associated with diabetes mellitus insulin-dependent
type 19. [provided by RefSeq, Jul 2012] RNA helicase that, through its ATP-dependent
unwinding of RNA, may function to promote message degradation by specific
RNases. Seems to have growth suppressive properties. Involved in innate
immune defense against viruses. Upon interaction with intracellular dsRNA
produced during viral replication, triggers a transduction cascade involving
MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and
the induction of the expression of antiviral cytokines such as IFN-beta and
RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential
for the production of interferons in response to picornaviruses. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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