簡要描述:熱休克蛋白90β2抗體免 疫 原;KLH conjugated synthetic peptide derived from human HSP90B2P: 261-360/399
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熱休克蛋白90β2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
熱休克蛋白90β2抗體 | HSP90B2P | GOY-01K5521 |
商品屬性:
英文名稱: HSP90B2P
中文名:熱休克蛋白90β2抗體
別 名;GRP94P1; Heat
shock protein 90kDa beta (Grp94) member 2; HSP; HSPCP2; Putative endoplasmin
like protein; Putative heat shock protein 90 kDa beta member 2; TRA1P1; TRAP1.
研究領(lǐng)域;細(xì)胞生物 信號轉(zhuǎn)導(dǎo)
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;46kDa
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human HSP90B2P: 261-360/399
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件;Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Hsp90 is a member of the heat shock protein 90
family that functions as a molecular chaperone and has ATPase activity. Hsp90
family proteins are highly conserved between isoforms and species. Several
signal transduction pathways depend on Hsp90 function including erbB2,
steroid hormone receptors (such as androgen, progesterone, glucocorticoid,
and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show
that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from
tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The
mechanism of this differential sensitivity of normal versus tumor Hsp90 is
not known (although mutation has been ruled out). One possible mechanism may
be differences in post-translational modification of tumor Hsp90. Hsp90 is a
cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34,
AHSA1, HDAC6 and SMYD3. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價,按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時,也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價,按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺,能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù),如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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