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簡要描述：甲狀旁腺功能亢進(jìn)蛋白2/細(xì)胞分裂周期73抗體注意事項；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品型號：GOY-01K1613廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：125產(chǎn)品分類
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甲狀旁腺功能亢進(jìn)蛋白2/細(xì)胞分裂周期73抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
甲狀旁腺功能亢進(jìn)蛋白2/細(xì)胞分裂周期73抗體 | HRPT2 | GOY-01K1613 |
商品屬性：
英文名稱: HRPT2
中文名:甲狀旁腺功能亢進(jìn)蛋白2/細(xì)胞分裂周期73抗體
別 名；C1orf28; CDC 73;
CDC73; Cell division cycle 73; Cell division cycle 73 Paf1/RNA polymerase II
complex component homolog; Cell division cycle protein 73 homolog; FLJ23316;
HPT-JT; HRPT 2; Hyperparathyroidism 2 (with jaw tumor); Hyperparathyroidism 2;
Hyperparathyroidism 2 protein; Parafibromin; CDC73_HUMAN.
研究領(lǐng)域；腫瘤 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；60kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HRPT2: 61-160/531
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The HRPT2 gene product, parafibromin, is a tumor
suppressor protein that is part of the human Paf1 complex. The yeast
counterpart to this complex is part of the RNA polymerase II complex as well,
and is important for histone modification and connections to
posttranscriptional events. Human parafibromin also associates with the RNA
polymerase II large subunit. Tumor suppressor probably involved in
transcriptional and post-transcriptional control pathways. May be involved in
cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
Component of the PAF1 complex (PAF1C) which has multiple functions during
transcription by RNA polymerase II and is implicated in regulation of
development and maintenance of embryonic stem cell pluripotency. PAF1C
associates with RNA polymerase II through interaction with POLR2A CTD
non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is
involved in transcriptional elongation, acting both indepentently and
synergistically with TCEA1 and in cooperation with the DSIF complex and
HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes.
PAF1C is involved in hematopoiesis and stimulates transcriptional activity of
KMT2A/MLL1; it promotes leukemogenesis through association with
KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and
KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as
ubiquitination of histone H2B and methylation on histone H3 'Lys-4'
(H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
and the E2 enzyme UBE2A or UBE2B to chromatin which mediate
monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated
H2B ubiquitination is proposed to be coupled to transcription. PAF1C is
involved in mRNA 3' end formation probably through association with cleavage
and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C
associates with viral NS1 protein, thereby regulating gene transcription.
Connects PAF1C with the cleavage and polyadenylation specificity factor
(CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with
Wnt signaling. Involved in polyadenylation of mRNA precursors. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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