簡要描述：轉(zhuǎn)錄調(diào)節(jié)因子HOXD9抗體免 疫 原；KLH conjugated synthetic peptide derived from human HOXD9: 251-352/352
產(chǎn)品型號：GOY-01K0574廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：146產(chǎn)品分類
Product Category相關(guān)文章
Related Articles詳細介紹
轉(zhuǎn)錄調(diào)節(jié)因子HOXD9抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
轉(zhuǎn)錄調(diào)節(jié)因子HOXD9抗體 | HOXD9 | GOY-01K0574 |
商品屬性：
英文名稱: HOXD9
中文名:轉(zhuǎn)錄調(diào)節(jié)因子HOXD9抗體
別 名；homeobox D9;
Homeobox protein Hox D9; Hox 4.3; Hox 5.2; HOX4; HOX4C; RP23 313J15.10;
HXD9_HUMAN.
研究領(lǐng)域；腫瘤 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；36kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HOXD9: 251-352/352
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The Hox proteins play a role in patterns of
embryonic development and cellular differentiation by regulating downstream
target genes. In vivo, the HoxD9 protein interacts with the autoregulatory
and cross-regulatory enhancers of the murine HoxB1 and human HoxD9 genes.
Specifically, the HoxD9 protein interacts with the human control region (HCR)
of the HoxD9 gene, thus inducing transcription of the HoxD9 promoter. HoxD9
may be a multifunctional transcriptional regulator, as it contains different
activation domains. Activation of HoxD9 depends on the structure of the
target regulatory element, and results in differential cofactor interaction.
The HoxD9 protein is expressed in the early stages of mouse joint
development, primarily in the articular cartilage. HoxD9 transcripts are also
detected in the synovial tissue of arthritic mice, but not in that of normal
mice, suggesting that HoxD9 may have a role in the pathology of arthritis.
Furthermore, the HoxD9 protein is highly expressed in the synoviocytes of
patients with rheumatoid arthritis (RA), but not in osteoarthritis patients.
The human HoxD9 protein is also differentially expressed in the human
cervical cancer cell line HeLa, but is not expressed in the normal cervix and
may thus play a role in tumorigenesis. Function: This gene belongs to the homeobox family of genes.
The homeobox genes encode a highly conserved family of transcription factors
that play an important role in morphogenesis in all multicellular organisms.
Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and
HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged
in tandem. This gene is one of several homeobox HOXD genes located at
2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene
cluster or 5' end of this cluster have been associated with severe limb and
genital abnormalities. The exact role of this gene has not been determined. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
產(chǎn)品咨詢
聯(lián)系人：
地址：
郵箱：
手機：18321818584 / 15026555973歡迎您關(guān)注我們的微信了解更多信息
掃一掃
歡迎來到
咨詢電話：