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簡(jiǎn)要描述：表皮生長(zhǎng)因子樣重復(fù)折疊1結(jié)構(gòu)域蛋白3抗體免 疫 原；KLH conjugated synthetic peptide derived from human EDIL3: 201-300/480
產(chǎn)品型號(hào)：GOY-01K0963廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：181產(chǎn)品分類
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表皮生長(zhǎng)因子樣重復(fù)折疊1結(jié)構(gòu)域蛋白3抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
表皮生長(zhǎng)因子樣重復(fù)折疊1結(jié)構(gòu)域蛋白3抗體 | EDIL3 | GOY-01K0963 |
商品屬性：
英文名稱: EDIL3
中文名:表皮生長(zhǎng)因子樣重復(fù)折疊1結(jié)構(gòu)域蛋白3抗體
別 名；DEL1;
Developmental endothelial locus 1; Developmentally regulated endothelial cell
locus 1 protein; EGF like repeat and discoidin I like domain containing protein
3; EGF like repeats and discoidin I like domains protein 3; Integrin binding
protein DEL1; EDIL3_HUMAN.
研究領(lǐng)域；心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 內(nèi)皮細(xì)胞 細(xì)胞骨架
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；52kDa
細(xì)胞定位；分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human EDIL3: 201-300/480
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
EDIL3 is an integrin ligand. It plays an important
role in mediating angiogenesis and may be important in vessel wall remodeling
and development. It also influences endothelial cell behavior.EGF-like repeat
and discoidin I-like domain-containing protein 3 (EDIL3; also Del-1 and
integrin-binding DEL1) is a 52 kDa extracellular matrix protein that is expressed
by endothelial tissues during embryonic vascular development. Human EDIL3 is
synthesized as a precursor with a 16 amino acid (aa) signal sequence and a
464 aa mature chain (SwissProt # O43854). The mature chain is composed of
three epidermal growth factor (EGF) repeats and two discoidin-I-like domains.
The second EGF repeat contains an RGD motif. Splicing variants produce two
isoforms for human EDIL3. Isoform 2 has an A -> G substitution at aa 66
and a deletion of aa 67-76 found in isoform 1. Mature human EDIL3 shares 96%
aa sequence identity with mature mouse EDIL3. The RGD motif of EDIL3 binds
alpha v beta 5 integrin, which, in turn, leads to increased angiogenic
transcription factor HoxD3 expression. HoxD3 activates alpha v beta 3 and
uPA, resulting in the transformation of resting endothelial cells to an
angiogenic state. EDIL3 becomes quiescent at the time of birth, and is no
longer expressed in normal adult tissues. It has been found, however,
re-expressed in a number of human tumors as well as in ischemic muscles and
ischemic brain tissue, which may play an important role in adult
angiogenesis. EDIL3 promotes adherence and migration of endothelial cells,
and acts as an endothelial cell survival agent through upregulation of Bcl-2
expression. Exogenous application of EDIL3 has been demonstrated to augment
angiogenesis and improve blood flow and tissue function in murine models of
hind-limb ischemia, cardiac ischemia and cerebral ischemia. EDIL3 has also
been shown to be an endogenous inhibitor of inflammatory cell recruitment by
interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion. Promotes adhesion of endothelial cells through
interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of
vascular-like structures. May be involved in regulation of vascular
morphogenesis of remodeling in embryonic development. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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