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簡要描述：ECSIT蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human ECSIT: 101-200/431
產(chǎn)品型號：GOY-01K2497廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：267產(chǎn)品分類
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ECSIT蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
ECSIT蛋白抗體 | ECSIT | GOY-01K2497 |
商品屬性：
英文名稱: ECSIT
中文名:ECSIT蛋白抗體
別 名；Ecsit; ECSIT
homolog; ECSIT protein; ECSIT_HUMAN; Evolutionarily conserved signaling
intermediate in Toll pathway; Evolutionarily conserved signaling intermediate
in Toll pathway, mitochondrial; Evolutionarily conserved signaling intermediate
in Toll pathways; Likely ortholog of mouse signaling intermediate in Toll
pathway evolutionarily conserved; Protein SITPEC; Signaling intermediate in
Toll pathway evolutionarily conserved; SITPEC; SITPEC protein.
研究領域；細胞生物 免疫學 信號轉(zhuǎn)導
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Dog, Cow, Sheep, )
產(chǎn)品應用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；44kDa
細胞定位；細胞核 細胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human ECSIT: 101-200/431
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
ECSIT is a 431 amino acid ubiquitously expressed
protein that plays an important role as an adaptor protein in the cytosolic
signal transduction cascade events triggered by Toll receptor activation.
Within the Toll pathway, ECSIT regulates MEKK1 processing for activation of
NFκB, a major event leading to
initiation of the innate immune response. In the mitochondria, ECSIT
interacts with NDUFAF1 and assists in the formation of NADH:ubiquinone
oxidoreductase (complex I), an extremely complicated multiprotein complex
located in the inner mitochondrial membrane that functions in the transport
of electrons from NADH to ubiquinone. Knockdown of ECSIT results in severely
impaired complex I assembly and disturbed mitochondrial function. There are
two isoforms of ECSIT that are produced as a result of alternative splicing
events Function: Adapter protein of the Toll-like and IL-1 receptor
signaling pathway that is involved in the activation of NF-kappa-B via
MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP
signaling pathway. Required for normal embryonic development (By similarity).
Required for efficient assembly of mitochondrial NADH:ubiquinone
oxidoreductase. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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