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簡要描述：E4F轉(zhuǎn)錄因子1抗體免 疫 原；KLH conjugated synthetic peptide derived from human E4F1: 151-250/784
產(chǎn)品型號(hào)：GOY-01K4234廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：147產(chǎn)品分類
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E4F轉(zhuǎn)錄因子1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
E4F轉(zhuǎn)錄因子1抗體 | E4F1 | GOY-01K4234 |
商品屬性：
英文名稱: E4F1
中文名:E4F轉(zhuǎn)錄因子1抗體
別 名；E4F; E4F
transcription factor 1, isoform CRA_b; P120E4F transcription factor;
E4F1_HUMAN.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；83kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human E4F1: 151-250/784
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This product
as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
E4F1, also known as E4F, is a 784 amino acid
protein that localizes to both the nucleus and the cytoplasm and contains
nine C2H2-type zinc fingers. Expressed ubiquitously in adult and fetal
tissues, E4F1 exists as a homodimer that binds DNA and is thought to act as a
transcriptional repressor and may also play a role in cell survival and
growth via cell cycle control. Additionally, E4F1 is thought to function as a
ubiquitin ligase that mediates the ubiquitination (and subsequent
degradation) of target proteins and may be involved in the p53 tumor
suppressor pathway. E4F1, which may be post-translationally phosphorylated or
sumoylated, is subject to proteolytic cleavage which results in the creation
of a short peptide with specific DNA binding capabilities. Function: May function as a transcriptional repressor. May
also function as a ubiquitin ligase mediating ubiquitination of
chromatin-associated TP53. Functions in cell survival and proliferation
through control of the cell cycle. Functions in the p53 and pRB tumor
suppressor pathways and regulates the cyclin CCNA2 transcription. [FUNCTION]
Identified as a cellular target of the adenoviral oncoprotein E1A, it is
required for both transcriptional activation and |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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