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簡要描述：精子尾部結構蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human Cenexin1: 1-100/829
產品型號：GOY-01K0289廠商性質：科研更新時間：2023-10-24 00:00:00訪 問 量：397產品分類
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精子尾部結構蛋白抗體
產品名稱 | 英文名稱 | 貨號 |
精子尾部結構蛋白抗體 | Cenexin1 | GOY-01K0289 |
商品屬性：
英文名稱: Cenexin1
中文名:精子尾部結構蛋白抗體
別 名；Cenexin1/ODF2;
sperm tail structural protein; 84 kDa outer dense fiber protein; Cenexin 1;
Cenexin1 variant 1; KKT 4; KKT4; ODF 2; ODF 84; ODF2; ODF2/1; ODF2/2; ODF84;
Outer dense fiber of sperm tail 2; Outer dense fiber of sperm tails 2; outer
dense fiber of sperm tails; Outer dense fiber of sperm tails protein 2; Outer
dense fiber of sperm tails, 84 kD; Outer dense fiber protein 2; Sperm outer
dense fiber major protein 2; Testis specific autoantigen; ODFP2_HUMAN.
研究領域；免疫學 發(fā)育生物學 信號轉導
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；Rat, (predicted: Human, )
產品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；91kDa
細胞定位；細胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Cenexin1: 1-100/829
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
Cenexin1 is an isoform of ODF2, that unlike ODF2
is present in several somatic cell types. Cenexin1 acts as a general scaffold
protein that is specifically localised to the distal/subdistal appendages of
mother centrioles. Cenexin1 is required for proper localization of Plk1 to
the centrosomes. This centrosomal localization of Plk1 is required for proper
microtubule function. Cenexin1 recruits Plk1 via a C-terminal extension of
cenexin1 that is not present in ODF2. Cenexin1 is required for proper mitotic
progression; depletion of Cenexin1 ultimately leads to chromosome
missegregation and apoptosis. The ODF2 (outer dense fiber 2) gene encodes
both ODF2 and Cenexin1, which have very different functions. ODF2 is a major
component of sperm tail outer dense fibers (ODFs). ODFs are filamentous
structures located on the outside of the axoneme in the midpiece and
principal piece of the mammalian sperm tail. They may help to maintain the
passive elastic structures and elastic recoil of the sperm tail, and may also
modulate sperm motility. Seems to be a major component of sperm tail outer
dense fibers (ODF). ODFs are filamentous structures located on the outside of
the axoneme in the midpiece and principal piece of the mammalian sperm tail
and may help to maintain the passive elastic structures and elastic recoil of
the sperm tail. May have a modulating influence on sperm motility. Functions
as a general scaffold protein that is specifically localized at the
distal/subdistal appendages of mother centrioles. Component of the centrosome
matrix required for the localization of PLK1 and NIN to the centrosomes.
Required for the formation and/or maintenance of normal CETN1 assembly. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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